IQdataNCA: Create an IQdataNCA object

In Quantmetrics770/IQnca: Noncompartmental Analysis in R

Create an IQdataNCA object

Description

Generates an IQdataNCA object. The minimum required columns (see getColumnNames_IQdataNCA) need to be present. Initial slope calculation will be conducted as well, based on the bestslope algorithm. This can later be refined but is useful to get a quick understanding of the data.

Usage

IQdataNCA(
  data,
  COMPTYPE = "exogenous",
  FLAGTIME = "actual",
  FATIMIMP = "asis",
  FLGBLQPR = "0",
  FLGBLQIN = "missing",
  FLGBLQP1 = "LLOQ/2",
  FLGBLQPO = "missing",
  FGBQPLIN = "asCONC",
  FGBQPLOG = "asCONC",
  AUCMETHD = "Linear Log",
  AUCINVAL = NA,
  SLOPETOL = 1e-04,
  FLAGoverwrite = TRUE,
  FLAGignore = TRUE
)

Arguments

data	data.frame with initial definitions
COMPTYPE	Type of compound: "exogenous" or "endogenous"
FLAGTIME	“actual”: actual time used in NCA PK parameter determination, “nominal”: nominal time used in NCA PK parameter determination. Default: "actual" It will be checked if ATIME is defined. If not, then "nominal" will be used.
FATIMIMP	Used in case if basis for analysis is actual time but some actual time point is missing. In this case the user can decide to impute this time point if the nominal time is available. “asis” or “nominal”. “asis”: if missing then it will not be imputed and not be considered in the analysis. If “nominal” then it will be imputed based on NTIME, NTAFD, NDUR and impact TIME, TAFD, and DUR. Default: "asis"
FLGBLQPR	Handling BLLOQ values before first observation above LLOQ. Options: "asis", "0", " LLOQ/2", "LLOQ", "missing".
FLGBLQIN	Handling BLLOQ values between observations above LLOQ. Options: "asis", "0", " LLOQ/2", " LLOQ ", "missing".
FLGBLQP1	Handling first BLLOQ value after last observation above LLOQ. Options: "asis", "0", " LLOQ/2", " LLOQ ", "missing".
FLGBLQPO	Handling BLLOQ values after first BLLOQ post last observation above LLOQ. Options: "asis", "0", " LLOQ/2", " LLOQ ", "missing".
FGBQPLIN	Handling BLLOQ values in plots on linear Y axis "asCONC", asis", "0", " LLOQ/2", " LLOQ ", "missing".
FGBQPLOG	Handling BLLOQ values in plots on log Y axis "asCONC", "asis", "0", " LLOQ/2", " LLOQ ", "missing".
AUCMETHD	Defines AUC calculation method. "Linear Log", "LinearUp LogDown", "Linear LinearInterpolation", "Linear LinearLogInterpolation"
AUCINVAL	Character string defining one or more AUC intervals to be calculated. Example: AUCINVAL <- "[0;24];[0;48]". Note that separators are ";" to allow to store that information also in a CSV file!
SLOPETOL	Tolerance for bestslope algorithm
FLAGoverwrite	If TRUE then derived columns will be regenerated even if already provided in data (safest). If FALSE then the information in the provided columns will be kept as-is (requires to know exectly what to do).
FLAGignore	If TRUE then default rules for exclusion of records from summary tables and NCA parameter calculation are used when applicable (e.g. pre-dose samples >LLOQ). If FALSE then all samples by default are passed through as available in the input data. The first setting is for real use. The second is mainly to allow comparison with results from other NCA tools.

Value

IQdataNCA object

See Also

Other NCA Data: check_IQdataNCA(), dataSpec_IQdataNCA(), exportADNCA_IQdataNCA(), export_IQdataNCA(), ignoreNCA_IQdataNCA(), ignoreSUM_IQdataNCA(), ignorerecord_IQdataNCA(), ignoresubject_IQdataNCA(), load_IQdataNCA(), plot.IQdataNCA(), reportIgnoredSUMNCA_IQdataNCA()

Quantmetrics770/IQnca documentation built on Aug. 5, 2022, 5:39 p.m.