nca_IQdataNCA: Calculation of NCA PK parameters
In Quantmetrics770/IQnca: Noncompartmental Analysis in R
nca_IQdataNCA R Documentation
Calculation of NCA PK parameters
Description
Ignored: ignored subjects (IGNOREI), ignored records (IGNORER and IGNORENCA)
Computed parameters and algorithm settings fully controlled by settings in the
IQdataNCA object.
Usage
nca_IQdataNCA(data, milliLiter = FALSE, CTLASTwinnonlinbehavior = TRUE)
Arguments
data
IQdataNCA object
milliLiter
By default L (Liter) is used as a standard unit for volume. If desired, by setting this
flag to TRUE also mL (milliliter) can be used. This is defined here during the calculation of the
PK parameters and not in the dataset as numerically it will give the same results (with some commata shifts).
CTLASTwinnonlinbehavior
If BLLOQ handling rule is set to use LLOQ/2 or LLOQ
for the first BLLOQ value post last observable, then Clast and Tlast will be set based
on this first BLLOQ imputation. This is counterintuitive - but in order to be aligned
with Winnonlin we had to add this exception. We do so here as an option ...
Use TRUE by default.
Value
IQnca object with calculated parameters. IQdataNCA object is added as attribute "dataNCA".
Information about column names and labels for interval AUC is also stored as attributes.
Quantmetrics770/IQnca documentation built on Aug. 5, 2022, 5:39 p.m.
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| nca_IQdataNCA | R Documentation |
Calculation of NCA PK parameters
Description
Ignored: ignored subjects (IGNOREI), ignored records (IGNORER and IGNORENCA) Computed parameters and algorithm settings fully controlled by settings in the IQdataNCA object.
Usage
nca_IQdataNCA(data, milliLiter = FALSE, CTLASTwinnonlinbehavior = TRUE)
Arguments
data |
IQdataNCA object |
milliLiter |
By default L (Liter) is used as a standard unit for volume. If desired, by setting this flag to TRUE also mL (milliliter) can be used. This is defined here during the calculation of the PK parameters and not in the dataset as numerically it will give the same results (with some commata shifts). |
CTLASTwinnonlinbehavior |
If BLLOQ handling rule is set to use LLOQ/2 or LLOQ for the first BLLOQ value post last observable, then Clast and Tlast will be set based on this first BLLOQ imputation. This is counterintuitive - but in order to be aligned with Winnonlin we had to add this exception. We do so here as an option ... Use TRUE by default. |
Value
IQnca object with calculated parameters. IQdataNCA object is added as attribute "dataNCA". Information about column names and labels for interval AUC is also stored as attributes.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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