derive_vars_crit_flag: Derive Criterion Flag Variables 'CRITy', 'CRITyFL', and...

In Roche-GSK/admiral: ADaM in R Asset Library

Derive Criterion Flag Variables CRITy, CRITyFL, and CRITyFN

Description

The function derives ADaM compliant criterion flags, e.g., to facilitate subgroup analyses.

If a criterion flag can't be derived with this function, the derivation is not ADaM compliant. It helps to ensure that

• the condition of the criterion depends only on variables of the same row,

• the CRITyFL is populated with valid values, i.e, either "Y" and NA or "Y", "N", and NA,

• the CRITy variable is populated correctly, i.e.,

  • set to a constant value within a parameter if CRITyFL is populated with "Y", "N", and NA and

  • set to a constant value within a parameter if the criterion condition is fulfilled and to NA otherwise if CRITyFL is populated with "Y", and NA

Usage

derive_vars_crit_flag(
  dataset,
  crit_nr = 1,
  condition,
  description,
  values_yn = FALSE,
  create_numeric_flag = FALSE
)

Arguments

dataset	Input dataset Default value none
crit_nr	The criterion number, i.e., the y in CRITy Permitted values a positive integer Default value 1
condition	Condition for flagging records See description of the values_yn argument for details on how the CRITyFL variable is populated. Permitted values an unquoted expression which evaluates to a logical (in dataset) Default value none
description	The description of the criterion The CRITy variable is set to the specified value. An expression can be specified to set the value depending on the parameter. Please note that the value must be constant within a parameter. Permitted values an unquoted expression which evaluates to a character (in dataset) Default value none
values_yn	Should "Y" and "N" be used for CRITyFL? If set to TRUE, the CRITyFL variable is set to "Y" if the condition (condition) evaluates to TRUE, it is set to "N" if the condition evaluate to FALSE, and to NA if it evaluates to NA. Otherwise, the CRITyFL variable is set to "Y" if the condition (condition) evaluates to TRUE, and to NA otherwise. Permitted values TRUE, FALSE Default value FALSE
create_numeric_flag	Create a numeric flag? If set to TRUE, the CRITyFN variable is created. It is set to 1 if CRITyFL == "Y", it set to 0 if CRITyFL == "N", and to NA otherwise. Permitted values TRUE, FALSE Default value FALSE

Value

The input dataset with the variables CRITy, CRITyFL, and optionally CRITyFN added.

See Also

BDS-Findings Functions that returns variable appended to dataset: derive_basetype_records(), derive_var_analysis_ratio(), derive_var_anrind(), derive_var_atoxgr(), derive_var_atoxgr_dir(), derive_var_base(), derive_var_chg(), derive_var_ontrtfl(), derive_var_pchg(), derive_var_shift()

Examples

library(tibble)
adbds <- tribble(
  ~PARAMCD, ~AVAL,
  "AST",    42,
  "AST",    52,
  "AST",    NA_real_,
  "ALT",    33,
  "ALT",    51
)

# Create a criterion flag with values "Y" and NA
derive_vars_crit_flag(
  adbds,
  condition = AVAL > 50,
  description = "Absolute value > 50"
)

# Create criterion flag with values "Y", "N", and NA and parameter dependent
# criterion description
derive_vars_crit_flag(
  adbds,
  crit_nr = 2,
  condition = AVAL > 50,
  description = paste(PARAMCD, "> 50"),
  values_yn = TRUE,
  create_numeric_flag = TRUE
)

Roche-GSK/admiral documentation built on April 14, 2025, 12:36 p.m.