All Model AD RNAseq is carried out using standardized protocols. Note that the two centers use slightly different protocols. UCI performs RNAseq on both hippocampus and cortex, while IU/Jax/Pitt performs RNAseq on hemibrains.
Log2 fold change has been computed for each model x sex x age combination in comparison to predefined controls, as follows:
Both UCI and IU/Jax/Pitt centers have characterized the 5xFAD model; other mouse models were characterized by only one of the two centers.
View sequencing data in the AD Knowledge Portal
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