SamirRachidZaim/referenceNof1: ‘Develops Robust Nof1 Reference Standards for Single-Subject Studies in Precision Medicine’

The referenceNof1 is an R package to further enable precision medicine in single-subject studies. Given the disagreements that may occur in methods of differential gene expression, we propose a new algorithm, *referenceNof1*, to systematically identify regions in the transcriptome that maximize concordance across techniques to maximize biological signal and minimize statisitcal noise. These tools are developed in single-subject paired design studies, that use fold change and expression-level filters to conduct a grid search to identify the optimal parameters for constructing an optimal reference standard.

install.packages("remotes")
remotes::install_github("SamirRachidZaim/referenceNof1")