READMEma.md

In SharonLutz/reverseC: This package contains methods to run mediation analysis and MR with reverse causality

reverseC for Mediation Analysis

These functions examines the performance of mediation analysis methods in the presence of reverse causality.

Installation

# you need R v3.4 or higher
# devtools must be installed first
install.packages("devtools") 
install.packages("mediation")
install.packages("MendelianRandomization") 

#this package does not install automatically, but is needed by TwoSampleMR
install.packages("psych")

# this is a dependency not present in R CRAN, it should be installed before reverseC
devtools::install_github("MRCIEU/TwoSampleMR") 

devtools::install_github("SharonLutz/reverseC")

Example:

library(reverseC)
?reverseMAsim # For details on this function

reverseMAsim(n = 1000, pX = 0.2, gamma0 = 0, gammaX = 0.2, varM = 1, beta0 = 0, betaX = 0, 
betaM = c(0.1, 0.2, 0.3), varY = 1, nSim = 500, nSimImai = 500, SEED = 1, plot.pdf = T, 
plot.name = "reverseMAplot.pdf", alpha_level = 0.05)

 reverseMAsim(n = 1000, pX = 0.2, gamma0 = 0, gammaX = 0, varM = 1, beta0 = 0, betaX = 0.2, 
betaM = c(0.1, 0.2, 0.3), varY = 1, nSim = 500, nSimImai = 500, SEED = 1, plot.pdf = T, 
plot.name = "reverseMAplotDirect.pdf", alpha_level = 0.05)

 reverseMAsim(n = 1000, pX = 0.2, gamma0 = 0, gammaX = 0.2, varM = 1, beta0 = 0, betaX = 0.2, 
betaM = c(0.1, 0.2, 0.3), varY = 1, nSim = 500, nSimImai = 500, SEED = 1, plot.pdf = T, 
plot.name = "reverseMAplotBoth.pdf", alpha_level = 0.05)

Output

SharonLutz/reverseC documentation built on Aug. 29, 2019, 5:58 a.m.