n50DE221rep1: A simulated dataset of read counts of 50 samples and 10,000...

Description Usage Format Details

Description

The first 25 samples belong to one group, and the rest 25 samples belong to the other group.

Usage

1

Format

A list of:

observed_read_count

A matrix of 10,000 x 50 genes generated using negative binomial distribution.

rho

A 50 x 3 matrix of cellular frequencies.

clinical_variables

A matrix of one cell type-independent covariate, RIN.

d

Numeric. A vector of 50 sample read depths.

Details

Within the first 2,000 genes, the first and second cell types are differentially expressed between two groups, but the third cell type is not differentially expressed. The power is generally low to detect them. The rest 8,000 genes have no cell type-specific differential expression.

The cellular frequencies roughly centers around 6:1:3 for the three cell types.

The dataset is generated using the config "n_50_DE_pattern_2_2_1_replicate_1".


Sun-lab/CARseq documentation built on Oct. 7, 2021, 1:52 p.m.