Thakar-Lab/FUNNEL-GSEA-R-Package: FUNNEL-GSEA: FUNctioNal ELastic-net Regression in time-course Gene Set Enrichment Analysis
This is a statistical inference framework for GSEA based on FUNctioNal ELastic-net regression, which utilizes the temporal information based on functional principal component analysis (FPCA), and disentangles the effects of overlapping genes by a functional extension of the elastic-net regression. It then performs hypothesis testing for gene sets by an extension of Mann-Whitney U test which is based on weighted rank sums computed from correlated observations.
Getting started
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Package details |
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| Author | Yun Zhang, Juilee Thakar, Xing Qiu |
| Maintainer | Yun Zhang <yun_zhang@urmc.rochester.edu>; Xing Qiu <xing_qiu@urmc.rochester.edu> |
| License | GPL-3 |
| Version | 1.0.0 |
| Package repository | View on GitHub |
| Installation |
Install the latest version of this package by entering the following in R:
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