This is a statistical inference framework for GSEA based on FUNctioNal ELastic-net regression, which utilizes the temporal information based on functional principal component analysis (FPCA), and disentangles the effects of overlapping genes by a functional extension of the elastic-net regression. It then performs hypothesis testing for gene sets by an extension of Mann-Whitney U test which is based on weighted rank sums computed from correlated observations.
|Author||Yun Zhang, Juilee Thakar, Xing Qiu|
|Maintainer||Yun Zhang <[email protected]>; Xing Qiu <[email protected]>|
|Package repository||View on GitHub|
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