Thakar-Lab/FUNNEL-GSEA-R-Package: FUNNEL-GSEA: FUNctioNal ELastic-net Regression in time-course Gene Set Enrichment Analysis

This is a statistical inference framework for GSEA based on FUNctioNal ELastic-net regression, which utilizes the temporal information based on functional principal component analysis (FPCA), and disentangles the effects of overlapping genes by a functional extension of the elastic-net regression. It then performs hypothesis testing for gene sets by an extension of Mann-Whitney U test which is based on weighted rank sums computed from correlated observations.

Getting started

Package details

AuthorYun Zhang, Juilee Thakar, Xing Qiu
MaintainerYun Zhang <[email protected]>; Xing Qiu <[email protected]>
LicenseGPL-3
Version1.0.0
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("Thakar-Lab/FUNNEL-GSEA-R-Package")
Thakar-Lab/FUNNEL-GSEA-R-Package documentation built on June 8, 2017, 12:03 a.m.