WenjianBI/SPAGE: SaddlePoint Approximation implementation of GxE analysis

A scalable and accurate method, SPAGE (SaddlePoint Approximation implementation of GxE analysis), that is applicable for genome-wide scale phenome-wide GxE studies (PheWIS). SPAGE fits a genotype-independent logistic model only once across the whole-genome analysis to reduce computation cost and uses a saddlepoint approximation (SPA) to calibrate the test statistics for analysis of phenotypes with unbalanced case-control ratios.

Getting started

Package details

AuthorWenjian Bi; Shawn (Seunggeun) Lee
MaintainerWenjian Bi <wenjianb@umich.edu>
LicenseGPL (>= 2)
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
WenjianBI/SPAGE documentation built on June 30, 2020, 5:33 p.m.