WenjianBI/SPAGE: SaddlePoint Approximation implementation of GxE analysis
A scalable and accurate method, SPAGE (SaddlePoint Approximation implementation of GxE analysis), that is applicable for genome-wide scale phenome-wide GxE studies (PheWIS). SPAGE fits a genotype-independent logistic model only once across the whole-genome analysis to reduce computation cost and uses a saddlepoint approximation (SPA) to calibrate the test statistics for analysis of phenotypes with unbalanced case-control ratios.
Getting started
Browse package contents
Package details |
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| Author | Wenjian Bi; Shawn (Seunggeun) Lee |
| Maintainer | Wenjian Bi <wenjianb@umich.edu> |
| License | GPL (>= 2) |
| Version | 0.1.5 |
| Package repository | View on GitHub |
| Installation |
Install the latest version of this package by entering the following in R:
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