knitr::opts_chunk$set( collapse = TRUE, comment = "#>", fig.path = "man/figures/README-", out.width = "100%" )
Dimensionality reduction of spatial omic data can reveal shared, spatially structured patterns of expression across a collection of genomic features. We study strategies for discovering and interactively visualizing low-dimensional structure in spatial omic data based on the construction of neighborhood features. We design quantile and network-based spatial features that result in spatially consistent embeddings. A simulation compares embeddings made with and without neighborhood-based featurization, and a re-analysis of [Keren et al., 2019] illustrates the overall workflow. We provide an R package, NBFvis, to support computation and interactive visualization for the proposed dimensionality reduction approach.
You can install the released version of NBFvis from GitHub.
devtools::install_github("XTH1114/NBFvis")
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