Design optimizer

binsearchtol | binary search with arbitrary resolution |

buildTrial | Generate efficacy boundaries and then calculate trial... |

buildTrial_Maurer_Bretz_2013 | Generate efficacy boundaries and then calculate trial... |

cleanArgList | Clean a list of arguments (for internal use) |

feasibility_check | Check feasibility of power constraints |

get_case_perf_obj | Get trial performance for each case. |

getEffBoundFromOptimSoln | Get efficacy boundary from a solution found by... |

getEffBounds | Compute efficacy stopping boundaries for an adaptive... |

get_E_SS | Returns the expected sample size (mostly for internal use) |

get_perf_mat | Get matrix with trial design performance in each supplied... |

getSmoothBounds | Get smooth parametric boundaries for efficacy and futility |

min_E_SS_power_constraints | Sample objective function to minimize |

min_n_multistage | Find the smallest total sample size such that a multi-stage... |

optimizeTrial | Use simulated annealing to search over a space of trial... |

sann_random | A simulated annealing variant that re-evaluates the reference... |

simTrial | Simulate a trial to compute power, expected sample size, and... |

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