ld_matrix_LDLink: Retrieve LD matrix with LDLink

Description Usage Arguments

View source: R/bio_LD_matrix.R

Description

This function is a wrapper around LDlinkR::LDmatrix() that allows queries for greater than 1000 SNPs, and using an optional local cache file for faster look-ups. The LDlink API only allows queries of up to 1000s SNPs at a time. This function makes repeated calls to the API to build the appropriate LD matrix.

Usage

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ld_matrix_LDLink(
  snps,
  pop = "EUR",
  r2d = "r2",
  tokens = NULL,
  cache = NULL,
  cache_tokens = TRUE,
  max_query_size = 1000,
  progress = TRUE,
  compress = FALSE
)

Arguments

snps

List of variants, using an rsID or chromosome coordinate (e.g. "chr7:24966446")

pop

A 1000 Genomes Project population, default = "EUR"

r2d

Either "r2" for LD R2 or "d" for LD D', default = "r2"

tokens

List of LDLink tokens. If multiple tokens are provided, look-ups will be performed in parallel

cache

Name of an optional cache file to read/store results from/to

cache_tokens

Whether to save tokens in the exported LD cache file.

max_query_size

Max number of SNPs to pass to LDlinkR at a time

progress

Display a progress indicator

compress

Whether output rds should be compressed


adamleejohnson/r-tools documentation built on Jan. 7, 2022, 5:35 p.m.