db_xls_common.md

In adamryczkowski/ONWebDUALSimport: Routines for importing and merging databases for the ONWebDUALS project

% Adam Ryczkowski % df1 % Tue Feb 20 19:37:40 2018

Changes to data when transforming df1 into df2

All questions names are matched between the databases. All patients are matched between the databases. There are 12 366 changes to the values to the existing patients and existing questions between the databases, which is 103% of all non-missing values.

Changes to the patient ANTA-0002

• cannot convert value No to number in 62 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 43 questions: How many family members 1 had a history of ALS (q_100a_2), How many family members 2 had a history of ALS (q_100b_2), How many family members 3 had a history of ALS (q_100c_2), How many family members 1 had a history of FTD (q_101a_2), How many family members 2 had a history of FTD (q_101b_2), How many family members 3 had a history of FTD (q_101c_2), How many family members 1 had a history of Alzheimer disease (q_102a_2), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 18 questions: q_110d, q_111, q_123, q_124, q_125, q_126, q_127, ...q_136, q_137, q_138
• cannot convert value Yes to number in 16 questions: q_149d, q_149h, q_152h, q_156h, q_16b, q_24c, q_25d, ...q_28b, q_28c, q_29a
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_24, q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• NA removed in Creatinine level (or NF, NA, NR) (q_55a), Creatinine lower range (q_55b) and Creatinine upper range (q_55c)
• Normal replaces value Abnormal in q_60, q_61 and q_62
• Niece maternal added in Which family member 1 had a history of ALS (q_100a_1), Which family member 1 had a history of FTD (q_101a_1) and Which family member 1 had a history of Alzheimer disease (q_102a_1)
• Niece paternal added in Which family member 2 had a history of ALS (q_100b_1), Which family member 2 had a history of FTD (q_101b_1) and Which family member 2 had a history of Alzheimer disease (q_102b_1)
• Niece unknown line added in Which family member 3 had a history of ALS (q_100c_1), Which family member 3 had a history of FTD (q_101c_1) and Which family member 3 had a history of Alzheimer disease (q_102c_1)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 2 added in Number of children (q_110a) and Order of specialist 2 that observed the patient (q_154a_2)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• General Practitioner added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• factor variable q_16g doesn't have defined level No
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• Distal and proximal replaces value Proximal in Predominant impairment (q_18c)
• 1 Oro-facial added in 1st region (q_48a_r)
• 2b Right Upper limb – proximal added in 2nd region (q_48b_r)
• 3b Left Upper limb – proximal added in 3rd region (q_48c_r)
• 2a Right Upper limb – distal added in 4th region (q_48d_r)
• 3a Left Upper limb – distal added in 5th region (q_48e_r)
• 4b Right Lower limb – proximal added in 6th region (q_48f_r)
• 2017-11-14 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Speech combined with nonvocal communication to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Moderately excessive saliva; may have minimal drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Dietary consistency changes to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value Intermittent use of BiPAP to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had died (q_106_1a)
• Myocardial infarction added in What cause of death of family member 1 (q_106_1b)
• 90 added in Age of family member 1 at the moment of death (q_106_1d)
• 5 added in Mother´s number of siblings (q_107b)
• 3 added in Father´s number of siblings (q_108b)
• "housewife" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0011

• cannot convert value No to number in 65 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: Mother´s birth order (q_107a), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 15 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_135, q_136, q_138
• cannot convert value Yes to number in 13 questions: q_149a, q_152d, q_152e, q_152f, q_152h, q_156h, q_16a, ...q_28a, q_28b, q_28c
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_137, q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t) and 5th timing (q_48e_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_16g and q_24 doesn't have defined level No
• No replaces value Yes in q_19 and q_63
• NA removed in Total Cholesterol lower range (q_56b) and Triglycerides lower range (q_59b)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• other added in What cause of death of family member 1 (q_106_1b) and What cause of death of family member 2 (q_106_2b)
• "unknown" added in What other cause of death of family member 1 (q_106_1c) and What other cause of death of family member 2 (q_106_2c)
• 4 added in Father´s number of siblings (q_108b) and Number of siblings (q_110a2)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 4b Right Lower limb – proximal added in 1st region (q_48a_r)
• 5b Left Lower limb – proximal added in 2nd region (q_48b_r)
• 4a Right Lower limb – distal added in 3rd region (q_48c_r)
• 5a Left Lower limb – distal added in 4th region (q_48d_r)
• 1 Oro-facial added in 5th region (q_48e_r)
• Bulbar replaces value Cervical in Region2 (q_49b)
• Bulbar removed in Region3 (q_50a)
• 2017-12-05 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Not all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Can cut most foods, although clumsy and slow; some help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can turn alone or adjust sheets, but with great difficulty to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Nonambulatory functional movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Type II replaces value Type I in q_74
• Yes replaces value No in q_91a
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• A added in Abnormal C9orf72 repeat-expansion (q_98_1)
• Mutation found added in TBK1 mutation (q_98_2a)
• Father added in Which family member 1 had died (q_106_1a)
• 83 added in Age of family member 1 at the moment of death (q_106_1d)
• Son added in Which family member 2 had died (q_106_2a)
• 56 added in Age of family member 2 at the moment of death (q_106_2d)
• 9 added in Mother´s number of siblings (q_107b)
• 3 added in Father´s birth order (q_108a)
• "housewife" removed in Main Ocupation (q_139)
• General Practitioner added in First specialist who observed the patient (q_148)
• cannot convert value NA to integer in Time gap between first-second specialist (q_151)
• Cardiologist added in What specialist 1 observed the patient (q_154b_1)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0015

• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 57 questions: q_117a, q_117b, q_117c, q_118a, q_118c, q_119a, q_119b, ...q_38.1b, q_38.2a, q_38.2b
• 1 added in 31 questions: How many family members 1 had a history of ALS (q_100a_2), How many family members 1 had a history of Parkinson disease (q_103a_2), Mother´s birth order (q_107a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• cannot convert value Yes to number in 21 questions: q_118b, q_152d, q_152e, q_152f, q_152h, q_156h, q_16a, ...q_28c, q_29a, q_29b
• No removed in 18 questions: q_123, q_124, q_125, q_127, q_128, q_129, q_130, ...q_145, q_146, q_147
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Siblings' birth order (q_110a1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• factor variable q_24, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t) and 5th timing (q_48e_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116) and Did specialist 1 made diagnosis (q_154d_1)
• factor variable q_16g and q_30a doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• Country towns– 1000-5 000 removed in Place of living (q_143) and Place of living (q_144)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• NA removed in Time gap between first-second specialist (q_151) and Time gap between first medical observation and diagnosis (q_155)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 4a Right Lower limb – distal added in 1st region (q_48a_r)
• 2a Right Upper limb – distal added in 2nd region (q_48b_r)
• 5a Left Lower limb – distal added in 3rd region (q_48c_r)
• 3a Left Upper limb – distal added in 4th region (q_48d_r)
• 1 Oro-facial added in 5th region (q_48e_r)
• 2017-12-20 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Loss of useful speech to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Dietary consistency changes to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Mutation found removed in q_97a
• "SNP" removed in SOD1 mutation type (q_97b)
• Sister added in Which family member 1 had a history of ALS (q_100a_1)
• Uncle maternal added in Which family member 1 had a history of Parkinson disease (q_103a_1)
• Father added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "UNKNOWN" added in What other cause of death of family member 1 (q_106_1c)
• 60 added in Age of family member 1 at the moment of death (q_106_1d)
• 6 added in Mother´s number of siblings (q_107b)
• 3 added in Father´s birth order (q_108a)
• 7 added in Father´s number of siblings (q_108b)
• 9 added in Number of siblings (q_110a2)
• "officer" removed in Main Ocupation (q_139)
• "farmer" removed in Second Occupation (q_141)
• Rehabilitation specialist added in What specialist 1 observed the patient (q_154b_1)
• Neurologist added in What specialist 2 observed the patient (q_154b_2)
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0016

• cannot convert value No to number in 71 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Mother´s birth order (q_107a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 19 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_145, q_146, q_147
• cannot convert value Yes to number in q_149a, q_156h, q_16a, q_26a, q_27a, q_28a and q_28b
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t), 7th timing (q_48g_t) and 8th timing (q_48h_t)
• 2 added in Number of children (q_110a), Siblings' birth order (q_110a1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116) and Did specialist 1 made diagnosis (q_154d_1)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_16g and q_24 doesn't have defined level No
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Internal Medicine added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 3a Left Upper limb – distal added in 1st region (q_48a_r)
• 2a Right Upper limb – distal added in 2nd region (q_48b_r)
• 3b Left Upper limb – proximal added in 3rd region (q_48c_r)
• 2b Right Upper limb – proximal added in 4th region (q_48d_r)
• 7 Neck added in 5th region (q_48e_r)
• 5b Left Lower limb – proximal added in 6th region (q_48f_r)
• 4b Right Lower limb – proximal added in 7th region (q_48g_r)
• 1 Oro-facial added in 8th region (q_48h_r)
• 2018-01-11 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Detectable speech disturbances to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can turn alone or adjust sheets, but with great difficulty to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Mild unsteadiness or fatigue to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "SVA" added in What other cause of death of family member 1 (q_106_1c)
• 70 added in Age of family member 1 at the moment of death (q_106_1d)
• 7 added in Mother´s number of siblings (q_107b)
• 4 added in Father´s birth order (q_108a)
• 12 added in Father´s number of siblings (q_108b)
• 5 added in Number of siblings (q_110a2)
• "farmer" removed in Main Ocupation (q_139)
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0017

• cannot convert value No to number in 65 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 28 questions: Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in 13 questions: q_149b, q_152d, q_152e, q_152h, q_156h, q_16a, q_16c, ...q_28a, q_29a, q_29b
• 2 added in Mother´s birth order (q_107a), Father´s birth order (q_108a), Father´s number of siblings (q_108b), Siblings' birth order (q_110a1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t) and 8th timing (q_48h_t)
• factor variable q_26, q_28, q_30a, q_87a and q_99.c1 doesn't have defined level Yes
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 4. Handwriting (q_51_1.4) and ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• factor variable q_16g and q_24 doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 2a Right Upper limb – distal added in 1st region (q_48a_r)
• 2b Right Upper limb – proximal added in 2nd region (q_48b_r)
• 3b Left Upper limb – proximal added in 3rd region (q_48c_r)
• 3a Left Upper limb – distal added in 4th region (q_48d_r)
• 5a Left Lower limb – distal added in 5th region (q_48e_r)
• 4a Right Lower limb – distal added in 6th region (q_48f_r)
• 6 Respiratory symptoms added in 7th region (q_48g_r)
• Same time added in 7th timing (q_48g_t)
• 1 Oro-facial added in 8th region (q_48h_r)
• Thoracic replaces value Bulbar in Region3 (q_50a)
• 2018-01-11 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Early eating problems - occasional choking to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Needs attendant for self-care to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can initiate, but not turn or adjust sheets alone to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs when walking to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 1976 replaces value NA in Year of initiation of smoking (q_88b)
• Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Mutation found removed in q_97a
• "SNP" removed in SOD1 mutation type (q_97b)
• Father added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "CVA" added in What other cause of death of family member 1 (q_106_1c)
• 86 added in Age of family member 1 at the moment of death (q_106_1d)
• 4 added in Mother´s number of siblings (q_107b)
• 6 added in Number of siblings (q_110a2)
• "shepherd" removed in Main Ocupation (q_139)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_144a)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0018

• cannot convert value No to number in 65 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 28 questions: Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 14 questions: q_124, q_125, q_126, q_127, q_129, q_130, q_131, ...q_136, q_137, q_138
• cannot convert value Yes to number in 13 questions: q_149g, q_152e, q_152g, q_152h, q_156d, q_156h, q_16a, ...q_29a, q_29b, q_29c
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Mother´s birth order (q_107a), Father´s birth order (q_108a), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Multiple Sclerosis (q_64_4), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t) and 7th timing (q_48g_t)
• factor variable q_123, q_128, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g, q_24 and q_30a doesn't have defined level No
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 4. Handwriting (q_51_1.4) and ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA removed in LDL Cholesterol lower range (q_58b) and Triglycerides lower range (q_59b)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• other added in What cause of death of family member 1 (q_106_1b) and What cause of death of family member 2 (q_106_2b)
• "Unknown" added in What other cause of death of family member 1 (q_106_1c) and What other cause of death of family member 2 (q_106_2c)
• 3 added in Mother´s number of siblings (q_107b) and Father´s number of siblings (q_108b)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• "ANTC0009" added in Control subject code (q_3b)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 4a Right Lower limb – distal added in 1st region (q_48a_r)
• 4b Right Lower limb – proximal added in 2nd region (q_48b_r)
• 5a Left Lower limb – distal added in 3rd region (q_48c_r)
• 5b Left Lower limb – proximal added in 4th region (q_48d_r)
• 2a Right Upper limb – distal added in 5th region (q_48e_r)
• 3a Left Upper limb – distal added in 6th region (q_48f_r)
• 1 Oro-facial added in 7th region (q_48g_r)
• 2018-01-11 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Significant difficulty, considering using mechanical respiratory support to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• Type II replaces value Type I in q_74
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Mutation found removed in q_97a
• "SNP" removed in SOD1 mutation type (q_97b)
• Father added in Which family member 1 had died (q_106_1a)
• 58 added in Age of family member 1 at the moment of death (q_106_1d)
• Son added in Which family member 2 had died (q_106_2a)
• 53 added in Age of family member 2 at the moment of death (q_106_2d)
• 5 added in Number of children (q_110a)
• 6 added in Siblings' birth order (q_110a1)
• 9 added in Number of siblings (q_110a2)
• "farmer" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0022

• cannot convert value No to number in 71 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Mother´s birth order (q_107a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 13 questions: q_124, q_125, q_126, q_127, q_128, q_129, q_130, ...q_135, q_136, q_138
• cannot convert value Yes to number in q_121a, q_121b, q_16b, q_24a, q_24c, q_25a and q_26a
• factor variable q_123, q_132, q_137, q_24, q_26, q_30a and q_99.c1 doesn't have defined level Yes
• 2 added in Mother´s number of siblings (q_107b), Father´s birth order (q_108a), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_16g and q_28 doesn't have defined level No
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• General Practitioner added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 1 Oro-facial added in 1st region (q_48a_r)
• 3a Left Upper limb – distal added in 2nd region (q_48b_r)
• 3b Left Upper limb – proximal added in 3rd region (q_48c_r)
• 5a Left Lower limb – distal added in 4th region (q_48d_r)
• 2a Right Upper limb – distal added in 5th region (q_48e_r)
• 4a Right Lower limb – distal added in 6th region (q_48f_r)
• 2016-03-11 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Detectable speech disturbances to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Slight but definite excess of saliva in mouth; may have nightime drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Dietary consistency changes to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Significant difficulty, considering using mechanical respiratory support to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Needs extra pillows in order to sleep (>2) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value Intermittent use of BiPAP to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2005 replaces value NA in Year of initiation of smoking (q_88b)
• Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• Yes replaces value No in q_89a
• "Lithium" added in Drug(s) used in psychiatric medication (q_89b)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• "Gabapentine" replaces value "gabapentine" in Antiepileptc's name (q_92b)
• Wt/wt (normal) removed in q_97a
• Son added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "Unknown" added in What other cause of death of family member 1 (q_106_1c)
• 60 added in Age of family member 1 at the moment of death (q_106_1d)
• 9 added in Father´s number of siblings (q_108b)
• 7 added in Siblings' birth order (q_110a1)
• 8 added in Number of siblings (q_110a2)
• Head added in Head/Neck trauma > 5 years (q_116)
• "tourism" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient JENA0044

• cannot convert value No to number in 62 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 31 questions: Father´s birth order (q_108a), Father´s number of siblings (q_108b), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• cannot convert value Yes to number in 16 questions: q_122b, q_156a, q_156b, q_156c, q_156d, q_156e, q_156f, ...q_27a, q_28c, q_29a
• 2 added in Number of siblings (q_110a2), How long vigorous sport activity 1 (q_112b_1c), How long vigorous sport activity 2 (q_112b_2c), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• mmol/l added in Total Cholesterol unit (q_56d), HDL Cholesterol unit (q_57d), LDL Cholesterol unit (q_58d) and Triglycerides unit (q_59d)
• No removed in q_110d, q_145, q_146 and q_147
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 2 observed the patient (q_154b_2) and What specialist 3 observed the patient (q_154b_3)
• Same time added in 2nd timing (q_48b_t), 4th timing (q_48d_t) and 6th timing (q_48f_t)
• After added in 3rd timing (q_48c_t), 5th timing (q_48e_t) and 7th timing (q_48g_t)
• "No" removed in Second Occupation (q_141), Second Occupation (q_142) and Side effects of Riluzole (q_91c)
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• 4 added in Mother´s birth order (q_107a) and Mother´s number of siblings (q_107b)
• 3 added in Number of children (q_110a) and Order of specialist 3 that observed the patient (q_154a_3)
• "heating engineer" removed in Main Ocupation (q_139) and Main Ocupation (q_140)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Orthopaedist added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Jena added in Medical facility (facility_id)
• B Stubbendorf added in Physician recording the data (person_id)
• Not related added in q_3a
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• factor variable q_16g doesn't have defined level No
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Upper Limbs replaces value No in Sensory changes (q_39)
• Positive added in q_43
• 4a Right Lower limb – distal added in 1st region (q_48a_r)
• 5a Left Lower limb – distal added in 2nd region (q_48b_r)
• 4b Right Lower limb – proximal added in 3rd region (q_48c_r)
• 5b Left Lower limb – proximal added in 4th region (q_48d_r)
• 2a Right Upper limb – distal added in 5th region (q_48e_r)
• 3a Left Upper limb – distal added in 6th region (q_48f_r)
• 1 Oro-facial added in 7th region (q_48g_r)
• 2017-05-04 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Detectable speech disturbances to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Can cut most foods, although clumsy and slow; some help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• µmol/l·s added in CK unit (q_53d)
• g/l added in Albumin unit (q_54d)
• µmol/l added in Creatinine unit (q_55d)
• "Budesonid" replaces value "Budesonid Spray" in Steroid's name (q_95b)
• Wt/wt (normal) added in q_97a
• A added in Abnormal C9orf72 repeat-expansion (q_98_1)
• factor variable q_99.c1 doesn't have defined level Yes
• No replaces value Yes in q_111
• Cycling added in Type of vigorous sport activity 1 (q_112b_1a)
• Football added in Type of vigorous sport activity 2 (q_112b_2a)
• cannot convert value NA to integer in Time gap between first-second specialist (q_151)
• Yes added in Did specialist 3 made diagnosis (q_154d_3)
• "JENA" removed in centr_id
• 105 replaces value 286 in x

Changes to the patient ANTA-0001

• cannot convert value No to number in 68 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 39 questions: Mother´s birth order (q_107a), Mother´s number of siblings (q_107b), Father´s birth order (q_108a), Father´s number of siblings (q_108b), Number of children (q_110a), Siblings' birth order (q_110a1), Number of siblings (q_110a2), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• NA removed in 26 questions: Time gap between first-second specialist (q_151), CK level (or NF, NA, NR) (q_53a), CK lower range (q_53b), CK upper range (q_53c), Albumin level (or NF, NA, NR) (q_54a), Albumin lower range (q_54b), Albumin upper range (q_54c), ...VC (% predicted values) (q_67), SNIP – absolute value (cmH2O) (q_70), Nocturnal oximetry - mean value (%) (q_71)
• No removed in 20 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_145, q_146, q_147
• cannot convert value Yes to number in q_149c, q_152e, q_152h, q_156h, q_16a, q_26a, q_27a, q_29a, q_29b and q_29c
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t) and 5th timing (q_48e_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g and q_24 doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10) and ALSFRS(1) 11. Orthopnea (q_51_1.11)
• Normal replaces value Abnormal in q_61 and q_62
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• Large town– > 100 000 removed in Place of living (q_143) and Place of living (q_144)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Neurologist added in What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2015-12-01 removed in Date of Invasive ventilation (q_14)
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 5a Left Lower limb – distal added in 1st region (q_48a_r)
• 4a Right Lower limb – distal added in 2nd region (q_48b_r)
• 2a Right Upper limb – distal added in 3rd region (q_48c_r)
• 3a Left Upper limb – distal added in 4th region (q_48d_r)
• 7 Neck added in 5th region (q_48e_r)
• Lumbo-sacral replaces value Cervical in Region1 (q_49a)
• Cervical replaces value Lumbo-sacral in Region2 (q_49b)
• Bulbar replaces value Thoracic in Region3 (q_50a)
• 2017-10-28 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Detectable speech disturbances to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Invasive mechanical ventilation by intubation or tracheostomy to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2013-01-01 replaces value 1905-07-05 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• "marketing staff" removed in Main Ocupation (q_139)
• "business manger" removed in Main Ocupation (q_140)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0003

• NA added in 90 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 67 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• No removed in 17 questions: q_111, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• cannot convert value Yes to number in 11 questions: q_152d, q_152h, q_16a, q_26a, q_26b, q_26c, q_27a, ...q_28b, q_28c, q_29a
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t) and 5th timing (q_48e_t)
• NA removed in Creatinine level (or NF, NA, NR) (q_55a), Creatinine lower range (q_55b), Creatinine upper range (q_55c) and SNIP – absolute value (cmH2O) (q_70)
• 3 added in Father´s birth order (q_108a), Father´s number of siblings (q_108b), Number of children (q_110a) and Siblings' birth order (q_110a1)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_16g and q_24 doesn't have defined level No
• Abnormal removed in q_61 and q_62
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 1 added in Mother´s birth order (q_107a) and Order of specialist 1 that observed the patient (q_154a_1)
• 2 added in Mother´s number of siblings (q_107b) and Order of specialist 2 that observed the patient (q_154a_2)
• Large town– > 100 000 added in Place of living (q_143) and Place of living (q_144)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Internal Medicine added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 3a Left Upper limb – distal added in 1st region (q_48a_r)
• 2a Right Upper limb – distal added in 2nd region (q_48b_r)
• 5a Left Lower limb – distal added in 3rd region (q_48c_r)
• 4a Right Lower limb – distal added in 4th region (q_48d_r)
• 7 Neck added in 5th region (q_48e_r)
• 2017-11-14 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Loss of useful speech to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Marked excess of saliva with some drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Needs supplemental tube feeding to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Normal removed in q_60
• No replaces value Yes in q_63
• 2007-01-01 replaces value 1905-06-29 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 7 added in Number of siblings (q_110a2)
• "farmer" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0004

• cannot convert value No to number in 59 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8), Mean number of packs/day (q_88e)
• cannot convert value Yes to number in 19 questions: q_149d, q_149e, q_149h, q_156d, q_156e, q_156h, q_16a, ...q_28a, q_28b, q_28c
• No removed in 18 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_145, q_146, q_147
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b) and ALS depression inventory lower range (q_47c)
• 2 added in Number of children (q_110a), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• factor variable q_133, q_24, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• mg/dl added in Creatinine unit (q_55d), Total Cholesterol unit (q_56d), HDL Cholesterol unit (q_57d), LDL Cholesterol unit (q_58d) and Triglycerides unit (q_59d)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t) and 4th timing (q_48d_t)
• 3 added in Father´s birth order (q_108a), Father´s number of siblings (q_108b) and Siblings' birth order (q_110a1)
• factor variable q_16g and q_30a doesn't have defined level No
• 4 added in Mother´s birth order (q_107a) and Mother´s number of siblings (q_107b)
• "carpenter" removed in Main Ocupation (q_139) and Second Occupation (q_141)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2017-10-01 removed in Date of Death (q_15)
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 3a Left Upper limb – distal added in 1st region (q_48a_r)
• 3b Left Upper limb – proximal added in 2nd region (q_48b_r)
• 2b Right Upper limb – proximal added in 3rd region (q_48c_r)
• 4a Right Lower limb – distal added in 4th region (q_48d_r)
• Lumbo-sacral removed in Region3 (q_50a)
• 2017-11-22 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Speech combined with nonvocal communication to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Needs supplemental tube feeding to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Nonambulatory functional movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Needs extra pillows in order to sleep (>2) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value None to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• U/l added in CK unit (q_53d)
• g/dl added in Albumin unit (q_54d)
• No replaces value Yes in q_63
• 2014 replaces value NA in Year of initiation of smoking (q_88b)
• Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 2016-01-01 replaces value 1905-07-08 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 6 added in Number of siblings (q_110a2)
• Yes removed in q_111
• "ANTA" removed in centr_id

Changes to the patient ANTA-0005

• cannot convert value No to number in 73 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 14 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_135, q_136, q_138
• 2 added in How many family members 1 had a history of Alzheimer disease (q_102a_2), Number of siblings (q_110a2), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t) and 7th timing (q_48g_t)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1), What specialist 2 observed the patient (q_154b_2) and What specialist 3 observed the patient (q_154b_3)
• cannot convert value Yes to number in q_149e, q_156h, q_16a, q_27a and q_27b
• factor variable q_16g, q_24, q_28 and q_30a doesn't have defined level No
• factor variable q_133, q_137, q_26 and q_99.c1 doesn't have defined level Yes
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate), HDL Cholesterol level (or NF, NA, NR) (q_57a) and HDL Cholesterol lower range (q_57b)
• 3a Left Upper limb – distal added in 1st region (q_48a_r) and 3rd region (q_48c_r)
• 3b Left Upper limb – proximal added in 2nd region (q_48b_r) and 4th region (q_48d_r)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5) and ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• 7 added in Mother´s number of siblings (q_107b) and Father´s number of siblings (q_108b)
• 3 added in Father´s birth order (q_108a) and Order of specialist 3 that observed the patient (q_154a_3)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 4a Right Lower limb – distal added in 5th region (q_48e_r)
• 5a Left Lower limb – distal added in 6th region (q_48f_r)
• 6 Respiratory symptoms added in 7th region (q_48g_r)
• factor variable Region2 (q_49b) doesn't have defined level Thoracic
• 2017-11-22 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• U/l added in CK unit (q_53d)
• NA removed in LDL Cholesterol lower range (q_58b)
• No replaces value Yes in q_63
• 1999 replaces value NA in Year of initiation of smoking (q_88b)
• 2015 replaces value NA in Year of interruption of smoking (q_88d)
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• A added in Abnormal C9orf72 repeat-expansion (q_98_1)
• Aunt maternal added in Which family member 1 had a history of Alzheimer disease (q_102a_1)
• 5 added in Mother´s birth order (q_107a)
• "military officer" removed in Main Ocupation (q_139)
• "sergeant" removed in Main Ocupation (q_140)
• Yes added in Did specialist 3 made diagnosis (q_154d_3)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0006

• cannot convert value No to number in 69 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 31 questions: Mother´s birth order (q_107a), Father´s birth order (q_108a), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 17 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• cannot convert value Yes to number in q_149b, q_149e, q_149h, q_152h, q_156h, q_16a, q_26a, q_27a and q_28a
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t) and 7th timing (q_48g_t)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g, q_24 and q_30a doesn't have defined level No
• factor variable q_26, q_28 and q_99.c1 doesn't have defined level Yes
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Mother´s number of siblings (q_107b) and Number of siblings (q_110a2)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 3a Left Upper limb – distal added in 1st region (q_48a_r)
• 2a Right Upper limb – distal added in 2nd region (q_48b_r)
• 3b Left Upper limb – proximal added in 3rd region (q_48c_r)
• 2b Right Upper limb – proximal added in 4th region (q_48d_r)
• 5a Left Lower limb – distal added in 5th region (q_48e_r)
• 5b Left Lower limb – proximal added in 6th region (q_48f_r)
• 6 Respiratory symptoms added in 7th region (q_48g_r)
• Thoracic replaces value Bulbar in Region3 (q_50a)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Needs extra pillows in order to sleep (>2) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value None to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 4 added in Father´s number of siblings (q_108b)
• "driver" removed in Main Ocupation (q_139)
• "repairman" removed in Second Occupation (q_141)
• Large town– > 100 000 added in Place of living (q_143)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0008

• cannot convert value No to number in 61 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 28 questions: Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• cannot convert value Yes to number in 17 questions: q_122a, q_149a, q_149d, q_149e, q_149f, q_149g, q_149h, ...q_29a, q_29b, q_29c
• No removed in 17 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• 2 added in Mother´s birth order (q_107a), Father´s birth order (q_108a), Father´s number of siblings (q_108b), Siblings' birth order (q_110a1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 4. Handwriting (q_51_1.4), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5) and ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_16g, q_24 and q_30a doesn't have defined level No
• factor variable q_26, q_28 and q_99.c1 doesn't have defined level Yes
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116) and Did specialist 1 made diagnosis (q_154d_1)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• other added in What cause of death of family member 1 (q_106_1b) and What cause of death of family member 2 (q_106_2b)
• "Unknown" added in What other cause of death of family member 1 (q_106_1c) and What other cause of death of family member 2 (q_106_2c)
• 6 added in Mother´s number of siblings (q_107b) and Number of siblings (q_110a2)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 5a Left Lower limb – distal added in 1st region (q_48a_r)
• 5b Left Lower limb – proximal added in 2nd region (q_48b_r)
• 4a Right Lower limb – distal added in 3rd region (q_48c_r)
• 4b Right Lower limb – proximal added in 4th region (q_48d_r)
• 2b Right Upper limb – proximal added in 5th region (q_48e_r)
• 3b Left Upper limb – proximal added in 6th region (q_48f_r)
• 2017-11-30 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Mild unsteadiness or fatigue to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Yes replaces value No in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Pending added in Abnormal C9orf72 repeat-expansion (q_98_1)
• Father added in Which family member 1 had died (q_106_1a)
• 62 added in Age of family member 1 at the moment of death (q_106_1d)
• Son added in Which family member 2 had died (q_106_2a)
• 65 added in Age of family member 2 at the moment of death (q_106_2d)
• "housewife" removed in Main Ocupation (q_139)
• Cardiologist added in What specialist 1 observed the patient (q_154b_1)
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0012

• cannot convert value No to number in 64 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 51 questions: Other type of specialist 7 that observed the patient (q_154c_7), ALSFRS(2) 1. Speech (q_51_2.1), ALSFRS(2) 10. Dyspnea (q_51_2.10), ALSFRS(2) 11. Orthopnea (q_51_2.11), ALSFRS(2) 12. Respiratory insufficiency (q_51_2.12), ALSFRS(2) 2. Salivation (q_51_2.2), ALSFRS(2) 3. Swallowing (q_51_2.3), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 35 questions: Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), Regular specific diet - Paleo (High-protein, high-fat, low-carbohydrate) (q_114h), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in 14 questions: q_149d, q_149e, q_149f, q_149g, q_149h, q_152h, q_156h, ...q_27c, q_29a, q_29c
• 2 added in Mother´s birth order (q_107a), Father´s birth order (q_108a), Regular specific diet - No (q_114a), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - NA (q_65a_8), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t) and 7th timing (q_48g_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1), Did specialist 2 made diagnosis (q_154d_2), Did specialist 3 made diagnosis (q_154d_3) and Did specialist 4 made diagnosis (q_154d_4)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 2 observed the patient (q_154b_2), What specialist 3 observed the patient (q_154b_3) and What specialist 4 observed the patient (q_154b_4)
• factor variable q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• NA removed in Total Cholesterol lower range (q_56b), LDL Cholesterol lower range (q_58b) and Triglycerides lower range (q_59b)
• factor variable q_16g and q_24 doesn't have defined level No
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2) and ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• No replaces value Yes in q_63 and q_94a
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Mother´s number of siblings (q_107b) and Order of specialist 4 that observed the patient (q_154a_4)
• 5 added in Father´s number of siblings (q_108b) and Number of siblings (q_110a2)
• 3 added in Siblings' birth order (q_110a1) and Order of specialist 3 that observed the patient (q_154a_3)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Internal Medicine added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 4a Right Lower limb – distal added in 1st region (q_48a_r)
• 5a Left Lower limb – distal added in 2nd region (q_48b_r)
• 2a Right Upper limb – distal added in 3rd region (q_48c_r)
• 3a Left Upper limb – distal added in 4th region (q_48d_r)
• 1 Oro-facial added in 5th region (q_48e_r)
• 8 Thoracic/abdomen added in 6th region (q_48f_r)
• 6 Respiratory symptoms added in 7th region (q_48g_r)
• 2017-12-19 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Significant difficulty, considering using mechanical respiratory support to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Unable to sleep to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value Invasive mechanical ventilation by intubation or tracheostomy to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Brother added in Which family member 1 had a history of other severe disease (q_105_1a)
• Cancer prostate added in What severe disease family member 1 had (q_105_1b)
• Yes removed in q_111
• "housewife" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0014

• cannot convert value No to number in 62 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: How many family members 1 had a history of Alzheimer disease (q_102a_2), Mother´s birth order (q_107a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 19 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_145, q_146, q_147
• cannot convert value Yes to number in 16 questions: q_149d, q_149e, q_152h, q_156h, q_16a, q_24c, q_26a, ...q_28c, q_29a, q_29b
• 2 added in Number of children (q_110a), Siblings' birth order (q_110a1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t), 6th timing (q_48f_t) and 7th timing (q_48g_t)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_24, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g and q_30a doesn't have defined level No
• NA removed in Total Cholesterol lower range (q_56b) and Triglycerides lower range (q_59b)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Father´s birth order (q_108a) and Number of siblings (q_110a2)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2011-04-02 replaces value 2011-02-04 in Date of Diagnosis (q_13)
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 3a Left Upper limb – distal added in 1st region (q_48a_r)
• 3b Left Upper limb – proximal added in 2nd region (q_48b_r)
• 2a Right Upper limb – distal added in 3rd region (q_48c_r)
• 2b Right Upper limb – proximal added in 4th region (q_48d_r)
• 5a Left Lower limb – distal added in 5th region (q_48e_r)
• 4a Right Lower limb – distal added in 6th region (q_48f_r)
• 1 Oro-facial added in 7th region (q_48g_r)
• 2017-12-20 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Detectable speech disturbances to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Slight but definite excess of saliva in mouth; may have nightime drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Early eating problems - occasional choking to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Able to grip pen but unable to write to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Needs attendant for self-care to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can initiate, but not turn or adjust sheets alone to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Nonambulatory functional movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Some difficulty sleeping at night due to shortness of breath (does not routinely use more than two pillows) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value None to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Mother added in Which family member 1 had a history of Alzheimer disease (q_102a_1)
• 5 added in Mother´s number of siblings (q_107b)
• 6 added in Father´s number of siblings (q_108b)
• "marketing" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0019

• cannot convert value No to number in 63 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 31 questions: Mother´s birth order (q_107a), Number of children (q_110a), Order of specialist 1 that observed the patient (q_154a_1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in 15 questions: q_149g, q_156h, q_16a, q_24c, q_25a, q_25b, q_25c, ...q_28a, q_28b, q_29a
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Siblings' birth order (q_110a1), Number of siblings (q_110a2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• factor variable q_24, q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116) and Did specialist 1 made diagnosis (q_154d_1)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 5 added in Mother´s number of siblings (q_107b) and Father´s number of siblings (q_108b)
• "trainer" removed in Main Ocupation (q_139) and Second Occupation (q_141)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• General Practitioner added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2016-08-15 replaces value 2015-08-15 in Date of Invasive ventilation (q_14)
• factor variable q_16g doesn't have defined level No
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 5a Left Lower limb – distal added in 1st region (q_48a_r)
• 4a Right Lower limb – distal added in 2nd region (q_48b_r)
• 3a Left Upper limb – distal added in 3rd region (q_48c_r)
• 2a Right Upper limb – distal added in 4th region (q_48d_r)
• 6 Respiratory symptoms added in 5th region (q_48e_r)
• 7 Neck added in 6th region (q_48f_r)
• 2018-02-08 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Loss of useful speech to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Marked drooling; requires constant tissue or handkerchief to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value NPO (exclus. parenteral or enteral feeding) to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Able to grip pen but unable to write to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Food must be cut by someone, but can still feed slowly to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Significant difficulty, considering using mechanical respiratory support to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Some difficulty sleeping at night due to shortness of breath (does not routinely use more than two pillows) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value Invasive mechanical ventilation by intubation or tracheostomy to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 3 added in Father´s birth order (q_108a)
• Yes removed in q_111
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0020

• cannot convert value No to number in 67 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Father´s birth order (q_108a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in 11 questions: q_152d, q_152e, q_152h, q_156h, q_16a, q_24c, q_25a, ...q_26b, q_27a, q_28b
• 2 added in Mother´s birth order (q_107a), Siblings' birth order (q_110a1), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_24, q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 6th timing (q_48f_t) and 7th timing (q_48g_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• Same time added in 5th timing (q_48e_t) and 8th timing (q_48h_t)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Mother´s number of siblings (q_107b) and Number of siblings (q_110a2)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• General Practitioner added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• factor variable q_16g doesn't have defined level No
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Positive added in q_43
• 2a Right Upper limb – distal added in 1st region (q_48a_r)
• 3a Left Upper limb – distal added in 2nd region (q_48b_r)
• 2b Right Upper limb – proximal added in 3rd region (q_48c_r)
• 3b Left Upper limb – proximal added in 4th region (q_48d_r)
• 1 Oro-facial added in 5th region (q_48e_r)
• 5a Left Lower limb – distal added in 6th region (q_48f_r)
• 4a Right Lower limb – distal added in 7th region (q_48g_r)
• 8 Thoracic/abdomen added in 8th region (q_48h_r)
• Lumbo-sacral replaces value Thoracic in Region3 (q_50a)
• cannot convert value Speech combined with nonvocal communication to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Slight but definite excess of saliva in mouth; may have nightime drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Dietary consistency changes to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can turn alone or adjust sheets, but with great difficulty to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 9 added in Father´s number of siblings (q_108b)
• Yes added in q_111
• "farmer" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0023

• cannot convert value No to number in 67 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: Mother´s birth order (q_107a), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in 11 questions: q_152d, q_152e, q_152h, q_156h, q_16a, q_26a, q_26b, ...q_28a, q_28b, q_29a
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t) and 5th timing (q_48e_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_26, q_30a and q_99.c1 doesn't have defined level Yes
• factor variable q_16g and q_24 doesn't have defined level No
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Father´s birth order (q_108a) and Number of siblings (q_110a2)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper limb replaces value Upper and lower in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 2 Right Upper limb – distal and proximal added in 1st region (q_48a_r)
• 3 Left Upper limb – distal and proximal added in 2nd region (q_48b_r)
• 4 Right Lower limb – distal and proximal added in 3rd region (q_48c_r)
• 5 Left Lower limb – distal and proximal added in 4th region (q_48d_r)
• 7 Neck added in 5th region (q_48e_r)
• Bulbar replaces value Thoracic in Region3 (q_50a)
• 2016-09-28 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Able to grip pen but unable to write to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Food must be cut by someone, but can still feed slowly to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Needs attendant for self-care to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can initiate, but not turn or adjust sheets alone to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Nonambulatory functional movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Some difficulty sleeping at night due to shortness of breath (does not routinely use more than two pillows) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value None to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• Yes replaces value No in q_89a
• "Lithium" added in Drug(s) used in psychiatric medication (q_89b)
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• "Homozygous D90A" replaces value "Homozigot D90A" in SOD1 mutation type (q_97b)
• 6 added in Mother´s number of siblings (q_107b)
• 5 added in Father´s number of siblings (q_108b)
• 3 added in Number of children (q_110a)
• Yes added in q_111
• "housewife" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0025

• cannot convert value No to number in 62 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 33 questions: How many family members 1 had a history of Alzheimer disease (q_102a_2), Father´s birth order (q_108a), Father´s number of siblings (q_108b), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), ...Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8), Mean number of packs/day (q_88e)
• cannot convert value Yes to number in 16 questions: q_149d, q_149e, q_149f, q_149g, q_149h, q_156h, q_16a, ...q_28a, q_28b, q_28c
• No removed in 13 questions: q_123, q_125, q_126, q_127, q_129, q_130, q_131, ...q_135, q_136, q_137
• factor variable q_124, q_128, q_138, q_24, q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b) and ALS depression inventory lower range (q_47c)
• 2 added in Number of children (q_110a), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• 3 added in Mother´s birth order (q_107a) and Number of siblings (q_110a2)
• No added in Head/Neck trauma in the last 5 years (q_115) and Did specialist 1 made diagnosis (q_154d_1)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2016-09-21 replaces value 2016-09-10 in Date of Invasive ventilation (q_14)
• factor variable q_16g doesn't have defined level No
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 3a Left Upper limb – distal added in 1st region (q_48a_r)
• 5a Left Lower limb – distal added in 2nd region (q_48b_r)
• 2a Right Upper limb – distal added in 3rd region (q_48c_r)
• 4a Right Lower limb – distal added in 4th region (q_48d_r)
• 1 Oro-facial added in 5th region (q_48e_r)
• 6 Respiratory symptoms added in 6th region (q_48f_r)
• 2016-09-20 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Intelligible with repeating to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Marked excess of saliva with some drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Dietary consistency changes to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Needs to be fed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Helpless to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value No purposeful leg movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Cannot do to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Significant difficulty, considering using mechanical respiratory support to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Some difficulty sleeping at night due to shortness of breath (does not routinely use more than two pillows) to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value Invasive mechanical ventilation by intubation or tracheostomy to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• NA replaces value 8 in ALSFRS-R total (q_51_1.score)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 1985 replaces value NA in Year of initiation of smoking (q_88b)
• 2010 replaces value NA in Year of interruption of smoking (q_88d)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Mother added in Which family member 1 had a history of Alzheimer disease (q_102a_1)
• 4 added in Mother´s number of siblings (q_107b)
• Head added in Head/Neck trauma > 5 years (q_116)
• "Driver" removed in Main Ocupation (q_139)
• "EMG" removed in Investigation requested by the 1st specialist (q_149)
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0026

• cannot convert value No to number in 71 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: Father´s birth order (q_108a), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 17 questions: q_111, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• cannot convert value Yes to number in q_149b, q_149e, q_152h, q_156h, q_16a, q_26a and q_28a
• 0 added in Age of family member 1 at the moment of death (q_106_1d), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• factor variable q_16g, q_24 and q_30a doesn't have defined level No
• factor variable q_26, q_28 and q_99.c1 doesn't have defined level Yes
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116) and Did specialist 1 made diagnosis (q_154d_1)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• General Practitioner added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• Distal and proximal replaces value Proximal in Predominant impairment (q_18c)
• 3b Left Upper limb – proximal added in 1st region (q_48a_r)
• 5b Left Lower limb – proximal added in 2nd region (q_48b_r)
• 3a Left Upper limb – distal added in 3rd region (q_48c_r)
• 5a Left Lower limb – distal added in 4th region (q_48d_r)
• 2a Right Upper limb – distal added in 5th region (q_48e_r)
• 2b Right Upper limb – proximal added in 6th region (q_48f_r)
• Cervical replaces value Lumbo-sacral in Region1 (q_49a)
• Lumbo-sacral replaces value Cervical in Region2 (q_49b)
• 2016-03-04 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Occurs with >= 1 of the following: eating, bathing, dressing (ADL) to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Mutation found removed in q_97a
• "SNP" removed in SOD1 mutation type (q_97b)
• Son added in Which family member 1 had died (q_106_1a)
• Other violent death added in What cause of death of family member 1 (q_106_1b)
• 6 added in Mother´s birth order (q_107a)
• 7 added in Mother´s number of siblings (q_107b)
• 4 added in Father´s number of siblings (q_108b)
• 3 added in Number of siblings (q_110a2)
• "housewife" removed in Main Ocupation (q_139)
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0054

• cannot convert value No to number in 61 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8), Mean number of packs/day (q_88e)
• cannot convert value Yes to number in 17 questions: q_119c, q_152d, q_156h, q_16a, q_24b, q_24c, q_25a, ...q_29a, q_29b, q_29c
• No removed in 16 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_135, q_136, q_138
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b) and ALS depression inventory lower range (q_47c)
• 2 added in Siblings' birth order (q_110a1), Number of siblings (q_110a2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• factor variable q_16g, q_24, q_26 and q_30a doesn't have defined level No
• "Cleaner" removed in Main Ocupation (q_139), Main Ocupation (q_140), Second Occupation (q_141) and Second Occupation (q_142)
• factor variable q_137, q_28 and q_99.c1 doesn't have defined level Yes
• 4 added in Mother´s birth order (q_107a) and Mother´s number of siblings (q_107b)
• 3 added in Father´s birth order (q_108a) and Father´s number of siblings (q_108b)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Orthopaedist added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• No replaces value Yes in q_37
• Lumbo-sacral removed in Region1 (q_49a)
• Cervical removed in Region2 (q_49b)
• Bulbar removed in Region3 (q_50a)
• 2017-06-24 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Intelligible with repeating to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Slight but definite excess of saliva in mouth; may have nightime drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Early eating problems - occasional choking to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Can cut most foods, although clumsy and slow; some help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Intermittent assistance or substitute methods to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Normal to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Slow to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs when walking to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• cannot convert value Unable to sleep to number in ALSFRS(1) 11. Orthopnea (q_51_1.11)
• cannot convert value Invasive mechanical ventilation by intubation or tracheostomy to number in ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• 28 removed in ALSFRS-R total (q_51_1.score)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Year of initiation of smoking (q_88b) doesn't allow for tagged NA 2
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "unknown" added in What other cause of death of family member 1 (q_106_1c)
• 84 added in Age of family member 1 at the moment of death (q_106_1d)
• Neurosurgeon added in Second specialist who observed the patient (q_150)
• Neurologist added in Specialist who made the diagnosis (q_153)
• Yes added in Did specialist 1 made diagnosis (q_154d_1)
• "ANTA" removed in centr_id
• 29 replaces value 54 in x

Changes to the patient ANTA-0055

• cannot convert value No to number in 65 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: Father´s birth order (q_108a), Father´s number of siblings (q_108b), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_135, q_136, q_137
• cannot convert value Yes to number in 13 questions: q_152g, q_156h, q_16b, q_24b, q_24c, q_25a, q_26a, ...q_28b, q_28c, q_29a
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_138, q_24, q_26 and q_99.c1 doesn't have defined level Yes
• 2 added in Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• "Housewife" removed in Main Ocupation (q_139), Main Ocupation (q_140), Second Occupation (q_141) and Second Occupation (q_142)
• factor variable q_16g, q_28 and q_30a doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Mother´s birth order (q_107a) and Mother´s number of siblings (q_107b)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Pneumologist added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2017-07-26 removed in Date of Death (q_15)
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Bulbar removed in Region1 (q_49a)
• Cervical removed in Region2 (q_49b)
• factor variable Region3 (q_50a) doesn't have defined level Cervical
• 2017-06-24 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Speech combined with nonvocal communication to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Moderately excessive saliva; may have minimal drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Dietary consistency changes to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Not all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Food must be cut by someone, but can still feed slowly to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Needs attendant for self-care to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can initiate, but not turn or adjust sheets alone to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Nonambulatory functional movement to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Mild unsteadiness or fatigue to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs at rest Shortness of breath at rest, difficulty breathing when either sitting or lying to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Yes replaces value No in q_63
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "UNKNOWN" added in What other cause of death of family member 1 (q_106_1c)
• 50 added in Age of family member 1 at the moment of death (q_106_1d)
• 13 added in Number of children (q_110a)
• 3 added in Siblings' birth order (q_110a1)
• 8 added in Number of siblings (q_110a2)
• Other added in Second specialist who observed the patient (q_150)
• Neurologist added in Specialist who made the diagnosis (q_153)
• Yes added in Did specialist 1 made diagnosis (q_154d_1)
• "ANTA" removed in centr_id
• 30 replaces value 55 in x

Changes to the patient ANTA-0007

• cannot convert value No to number in 67 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Mother´s birth order (q_107a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 19 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_145, q_146, q_147
• cannot convert value Yes to number in 11 questions: q_149d, q_149e, q_149f, q_149g, q_152h, q_156h, q_16a, ...q_27a, q_27b, q_28a
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t) and 5th timing (q_48e_t)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g, q_24 and q_30a doesn't have defined level No
• factor variable q_26, q_28 and q_99.c1 doesn't have defined level Yes
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Mother´s number of siblings (q_107b) and Father´s birth order (q_108a)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• 2014-05-04 replaces value 2014-05-02 in Date of Diagnosis (q_13)
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 2a Right Upper limb – distal added in 1st region (q_48a_r)
• 3a Left Upper limb – distal added in 2nd region (q_48b_r)
• 2b Right Upper limb – proximal added in 3rd region (q_48c_r)
• 3b Left Upper limb – proximal added in 4th region (q_48d_r)
• 4a Right Lower limb – distal added in 5th region (q_48e_r)
• 2017-11-30 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Unable to grip pen to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Food must be cut by someone, but can still feed slowly to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Intermittent assistance or substitute methods to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• Yes replaces value No in q_91a
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 7 added in Father´s number of siblings (q_108b)
• 4 added in Siblings' birth order (q_110a1)
• 9 added in Number of siblings (q_110a2)
• "warden" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0009

• cannot convert value No to number in 65 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8), Mean number of packs/day (q_88e)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in 13 questions: q_149d, q_149e, q_149g, q_156h, q_16a, q_24c, q_26a, ...q_28a, q_28b, q_29b
• factor variable q_24, q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b) and ALS depression inventory lower range (q_47c)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t) and 4th timing (q_48d_t)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• 4 added in Father´s birth order (q_108a), Father´s number of siblings (q_108b) and Siblings' birth order (q_110a1)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116) and Did specialist 1 made diagnosis (q_154d_1)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5) and ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• factor variable q_16g doesn't have defined level No
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 2b Right Upper limb – proximal added in 1st region (q_48a_r)
• 2a Right Upper limb – distal added in 2nd region (q_48b_r)
• 3b Left Upper limb – proximal added in 3rd region (q_48c_r)
• 3a Left Upper limb – distal added in 4th region (q_48d_r)
• Bulbar removed in Region2 (q_49b)
• 2017-12-04 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 3 added in Mother´s birth order (q_107a)
• 5 added in Mother´s number of siblings (q_107b)
• 6 added in Number of siblings (q_110a2)
• "driver" removed in Main Ocupation (q_139)
• "farmer" removed in Second Occupation (q_141)
• Cardiologist added in What specialist 1 observed the patient (q_154b_1)
• Yes added in Did specialist 2 made diagnosis (q_154d_2)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0010

• cannot convert value No to number in 69 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: Mother´s birth order (q_107a), Father´s birth order (q_108a), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in q_156h, q_16a, q_26a, q_26b, q_26c, q_27a, q_27b, q_28a and q_28b
• 0 added in Cognition - ECAS lower range (q_45b), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t), 4th timing (q_48d_t), 5th timing (q_48e_t) and 6th timing (q_48f_t)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• factor variable q_26, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 4. Handwriting (q_51_1.4), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5) and ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• factor variable q_16g and q_24 doesn't have defined level No
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Mother´s number of siblings (q_107b) and Number of children (q_110a)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower added in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 0 replaces value 136 in Cognition - ECAS upper range (q_45c)
• 5a Left Lower limb – distal added in 1st region (q_48a_r)
• 4a Right Lower limb – distal added in 2nd region (q_48b_r)
• 5b Left Lower limb – proximal added in 3rd region (q_48c_r)
• 4b Right Lower limb – proximal added in 4th region (q_48d_r)
• 3b Left Upper limb – proximal added in 5th region (q_48e_r)
• 2b Right Upper limb – proximal added in 6th region (q_48f_r)
• Thoracic removed in Region3 (q_50a)
• 2017-12-04 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 5 added in Father´s number of siblings (q_108b)
• 6 added in Siblings' birth order (q_110a1)
• 7 added in Number of siblings (q_110a2)
• "repairman" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0013

• cannot convert value No to number in 66 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 18 questions: q_124, q_125, q_126, q_127, q_128, q_129, q_130, ...q_145, q_146, q_147
• cannot convert value Yes to number in 12 questions: q_149d, q_149e, q_149f, q_152h, q_156h, q_16a, q_26b, ...q_27c, q_28a, q_28b
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Mother´s birth order (q_107a), Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 4. Handwriting (q_51_1.4), ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_123, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g, q_24 and q_30a doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• Distal and proximal replaces value Proximal in Predominant impairment (q_18c)
• 2b Right Upper limb – proximal added in 1st region (q_48a_r)
• 3b Left Upper limb – proximal added in 2nd region (q_48b_r)
• After added in 2nd timing (q_48b_t)
• 2017-12-20 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• Yes replaces value No in q_91a
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 6 added in Mother´s number of siblings (q_107b)
• 3 added in Father´s birth order (q_108a)
• 4 added in Father´s number of siblings (q_108b)
• 7 added in Number of siblings (q_110a2)
• "farmer" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0021

• cannot convert value No to number in 70 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 32 questions: Mother´s birth order (q_107a), Father´s birth order (q_108a), Father´s number of siblings (q_108b), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• cannot convert value Yes to number in q_149d, q_149h, q_152h, q_156h, q_16a, q_24c, q_26a and q_28a
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Tumor (q_65a_2), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153), What specialist 1 observed the patient (q_154b_1) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_24, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t) and 4th timing (q_48d_t)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• No added in Head/Neck trauma in the last 5 years (q_115), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• factor variable q_16g and q_30a doesn't have defined level No
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• "ANTC0008" added in Control subject code (q_3b)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 1 Oro-facial added in 1st region (q_48a_r)
• 2b Right Upper limb – proximal added in 2nd region (q_48b_r)
• 2a Right Upper limb – distal added in 3rd region (q_48c_r)
• 3b Left Upper limb – proximal added in 4th region (q_48d_r)
• Lumbo-sacral removed in Region3 (q_50a)
• 2016-03-01 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• "Lithium" replaces value "Litium" in Drug(s) used in psychiatric medication (q_89b)
• 2014-01-01 replaces value 1905-07-06 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 10 added in Mother´s number of siblings (q_107b)
• 4 added in Number of siblings (q_110a2)
• Head added in Head/Neck trauma > 5 years (q_116)
• "Teacher" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0024

• cannot convert value No to number in 74 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Order of specialist 2 that observed the patient (q_154a_2), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - Myelitis (q_65a_4), Spinal cord MRI Thoracic - Tumor (q_65b_2) and Spinal cord MRI Lumbo-sacral - Tumor (q_65c_2)
• factor variable q_24, q_26, q_28 and q_99.c1 doesn't have defined level Yes
• cannot convert value Yes to number in q_156h, q_25b, q_26b and q_28b
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• 3 added in Father´s birth order (q_108a), Number of siblings (q_110a2), How long moderate sport activity 1 (q_112a_1c) and How long moderate sport activity 2 (q_112a_2c)
• No added in Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), Did specialist 1 made diagnosis (q_154d_1) and Did specialist 2 made diagnosis (q_154d_2)
• After added in 2nd timing (q_48b_t), 3rd timing (q_48c_t) and 4th timing (q_48d_t)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 2 observed the patient (q_154b_2)
• factor variable q_16g and q_30a doesn't have defined level No
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Mother´s birth order (q_107a) and Mother´s number of siblings (q_107b)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Internal Medicine added in First specialist who observed the patient (q_148) and What specialist 1 observed the patient (q_154b_1)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• 2a Right Upper limb – distal added in 1st region (q_48a_r)
• 2b Right Upper limb – proximal added in 2nd region (q_48b_r)
• 1 Oro-facial added in 3rd region (q_48c_r)
• 3b Left Upper limb – proximal added in 4th region (q_48d_r)
• 2016-08-11 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Detectable speech disturbances to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• No replaces value Yes in q_63
• Yes replaces value No in q_89a
• "Lithium" added in Drug(s) used in psychiatric medication (q_89b)
• 2016-01-01 replaces value 1905-07-08 in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 5 added in Father´s number of siblings (q_108b)
• Basketball added in Type of moderate sport activity 1 (q_112a_1a)
• Fast walking added in Type of moderate sport activity 2 (q_112a_2a)
• "teacher" removed in Main Ocupation (q_139)
• "ANTA" removed in centr_id

Changes to the patient ANTA-0052

• cannot convert value No to number in 64 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 27 questions: Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), Spinal cord MRI Cervical - Tumor (q_65a_2), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 17 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• cannot convert value Yes to number in 14 questions: q_149d, q_152d, q_152h, q_156h, q_16b, q_24c, q_25b, ...q_28a, q_28b, q_28c
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Mother´s birth order (q_107a), Number of children (q_110a), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• cannot convert value Normal to number in ALSFRS(1) 4. Handwriting (q_51_1.4), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5), ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• factor variable q_16g, q_24, q_26 and q_30a doesn't have defined level No
• "Housewife" removed in Main Ocupation (q_139), Main Ocupation (q_140), Second Occupation (q_141) and Second Occupation (q_142)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• factor variable q_28 and q_99.c1 doesn't have defined level Yes
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 7 added in Mother´s number of siblings (q_107b) and Siblings' birth order (q_110a1)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 1975-06-20 replaces value 1962-06-20 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• No replaces value Yes in q_37
• Bulbar removed in Region1 (q_49a)
• Lumbo-sacral removed in Region2 (q_49b)
• factor variable Region3 (q_50a) doesn't have defined level Cervical
• 2017-06-23 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Speech combined with nonvocal communication to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Slight but definite excess of saliva in mouth; may have nightime drooling to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Early eating problems - occasional choking to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had died (q_106_1a)
• Myocardial infarction added in What cause of death of family member 1 (q_106_1b)
• 65 added in Age of family member 1 at the moment of death (q_106_1d)
• 3 added in Father´s birth order (q_108a)
• 5 added in Father´s number of siblings (q_108b)
• 8 added in Number of siblings (q_110a2)
• NA removed in Time gap between first-second specialist (q_151)
• "ANTA" removed in centr_id
• 27 replaces value 52 in x

Changes to the patient ANTA-0053

• cannot convert value No to number in 71 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 20 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_145, q_146, q_147
• cannot convert value Yes to number in q_149h, q_156h, q_27a, q_27c, q_29a, q_29b and q_29c
• 2 added in Mother´s birth order (q_107a), Number of siblings (q_110a2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_16g, q_24, q_26 and q_30a doesn't have defined level No
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5) and ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in First specialist who observed the patient (q_148), Specialist who made the diagnosis (q_153) and What specialist 1 observed the patient (q_154b_1)
• factor variable q_28 and q_99.c1 doesn't have defined level Yes
• 3 added in Mother´s number of siblings (q_107b) and Father´s birth order (q_108a)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• Distal and proximal replaces value Proximal in Predominant impairment (q_18c)
• Lumbo-sacral removed in Region1 (q_49a)
• Cervical removed in Region2 (q_49b)
• 2017-06-23 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• "Fluoxetine" replaces value "FLUOXETİNE" in Drug(s) used in psychiatric medication (q_89b)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had a history of other severe disease (q_105_1a)
• Cancer lung added in What severe disease family member 1 had (q_105_1b)
• Mother added in Which family member 2 had a history of other severe disease (q_105_2a)
• other added in What severe disease family member 2 had (q_105_2b)
• "stroke" added in What other severe disease family member 2 had (q_105_2c)
• 4 added in Father´s number of siblings (q_108b)
• "GRAFİC DESİGNER" removed in Main Ocupation (q_139)
• Large town– > 100 000 removed in Place of living (q_144)
• NA removed in Time gap between first-second specialist (q_151)
• Yes added in Did specialist 1 made diagnosis (q_154d_1)
• "ANTA" removed in centr_id
• 28 replaces value 53 in x

Changes to the patient ANTA-0056

• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 57 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• 1 added in 28 questions: Siblings' birth order (q_110a1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• cannot convert value Yes to number in 21 questions: q_149d, q_149e, q_149f, q_149g, q_149h, q_152d, q_152e, ...q_29a, q_29b, q_29c
• No removed in 17 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• 2 added in Mother´s birth order (q_107a), Father´s birth order (q_108a), Number of children (q_110a), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_16g, q_24, q_28 and q_30a doesn't have defined level No
• "farmer" removed in Main Ocupation (q_139), Main Ocupation (q_140), Second Occupation (q_141) and Second Occupation (q_142)
• factor variable q_26 and q_99.c1 doesn't have defined level Yes
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Father´s number of siblings (q_108b) and Number of siblings (q_110a2)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Neurologist added in First specialist who observed the patient (q_148) and Second specialist who observed the patient (q_150)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Cervical removed in Region1 (q_49a)
• Lumbo-sacral removed in Region2 (q_49b)
• Thoracic removed in Region3 (q_50a)
• 2017-06-24 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Able to grip pen but unable to write to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Can cut most foods, although clumsy and slow; some help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Total dependence to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Can initiate, but not turn or adjust sheets alone to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Needs assistance to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs at rest Shortness of breath at rest, difficulty breathing when either sitting or lying to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 8 added in Mother´s number of siblings (q_107b)
• No replaces value Yes in q_145
• "ANTA" removed in centr_id
• 31 replaces value 56 in x

Changes to the patient ANTA-0057

• cannot convert value No to number in 62 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 31 questions: Mother´s birth order (q_107a), Father´s birth order (q_108a), Siblings' birth order (q_110a1), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• cannot convert value Yes to number in 16 questions: q_149f, q_149g, q_152d, q_152e, q_152f, q_152g, q_152h, ...q_28b, q_29a, q_29b
• No removed in 15 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_135, q_136, q_138
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_134, q_137, q_28, q_30a and q_99.c1 doesn't have defined level Yes
• 2 added in Number of siblings (q_110a2), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• "mechanical enjineer" removed in Main Ocupation (q_139), Main Ocupation (q_140), Second Occupation (q_141) and Second Occupation (q_142)
• factor variable q_16g, q_24 and q_26 doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150) and What specialist 1 observed the patient (q_154b_1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2) and ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 1026-09-23 replaces value 2016-09-23 in Date of consultation (q_4)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Lumbo-sacral removed in Region1 (q_49a)
• Cervical removed in Region2 (q_49b)
• 2017-06-24 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Somewhat slow and clumsy, but no help needed to number in ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value Walks with assistance to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Mild unsteadiness or fatigue to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• Wt/wt (normal) removed in q_97a
• Father added in Which family member 1 had died (q_106_1a)
• other added in What cause of death of family member 1 (q_106_1b)
• "UNKNOWN" added in What other cause of death of family member 1 (q_106_1c)
• 67 added in Age of family member 1 at the moment of death (q_106_1d)
• 4 added in Mother´s number of siblings (q_107b)
• 3 added in Father´s number of siblings (q_108b)
• Yes added in Did specialist 1 made diagnosis (q_154d_1)
• "ANTA" removed in centr_id
• 32 replaces value 57 in x

Changes to the patient ANTA-0058

• cannot convert value No to number in 77 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Lives in Rural Area/Urban (q_143a), Lives in Rural Area/Urban (q_144a), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 20 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_145, q_146, q_147
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Number of children (q_110a), Siblings' birth order (q_110a1), Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 4. Handwriting (q_51_1.4), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5), ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• factor variable q_16g, q_24, q_26 and q_30a doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150) and Specialist who made the diagnosis (q_153)
• factor variable q_28 and q_99.c1 doesn't have defined level Yes
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Mother´s birth order (q_107a) and Father´s birth order (q_108a)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• cannot convert value Yes to number in q_16a
• Upper and lower replaces value Lower limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Cervical removed in Region1 (q_49a)
• Lumbo-sacral removed in Region2 (q_49b)
• 2017-06-24 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• 8 added in Mother´s number of siblings (q_107b)
• 11 added in Father´s number of siblings (q_108b)
• 7 added in Number of siblings (q_110a2)
• "ANTA" removed in centr_id
• 33 replaces value 58 in x

Changes to the patient ANTA-0060

• cannot convert value No to number in 69 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 27 questions: Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), Brain MRI - NA (q_64_7), Spinal cord MRI Cervical - Normal (q_65a_1), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 20 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_145, q_146, q_147
• cannot convert value Yes to number in q_149a, q_149h, q_152h, q_156h, q_16a, q_24c, q_26a, q_26b and q_26c
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2), ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5), ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7), ALSFRS(1) 8. Walking (q_51_1.8) and ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• 2 added in Number of children (q_110a), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - NA (q_65a_8), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• factor variable q_16g, q_24, q_28 and q_30a doesn't have defined level No
• cannot convert value None to number in ALSFRS(1) 10. Dyspnea (q_51_1.10), ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• 3 added in Mother´s birth order (q_107a), Father´s birth order (q_108a) and Siblings' birth order (q_110a1)
• 6 added in Mother´s number of siblings (q_107b), Father´s number of siblings (q_108b) and Number of siblings (q_110a2)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150) and Specialist who made the diagnosis (q_153)
• factor variable q_26 and q_99.c1 doesn't have defined level Yes
• Stroke - type unknown added in What severe disease family member 1 had (q_105_1b) and What cause of death of family member 1 (q_106_1b)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Cervical removed in Region1 (q_49a)
• Lumbo-sacral removed in Region2 (q_49b)
• Thoracic removed in Region3 (q_50a)
• 2017-06-25 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Intelligible with repeating to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Normal function to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2016 replaces value NA in Year of interruption of smoking (q_88d)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Wt/wt (normal) removed in q_97a
• Mother added in Which family member 1 had a history of other severe disease (q_105_1a)
• Father added in Which family member 1 had died (q_106_1a)
• 53 added in Age of family member 1 at the moment of death (q_106_1d)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_144a)
• "ANTA" removed in centr_id
• 35 replaces value 60 in x

Changes to the patient ANTA-0061

• cannot convert value No to number in 66 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 59 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 30 questions: Mother´s birth order (q_107a), Mother´s number of siblings (q_107b), Order of specialist 1 that observed the patient (q_154a_1), Brain MRI - Normal (q_64_1), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 17 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_136, q_137, q_138
• cannot convert value Yes to number in 12 questions: q_149d, q_149e, q_152h, q_156h, q_16a, q_26a, q_26b, ...q_27b, q_28a, q_28c
• 0 added in Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• 2 added in Number of children (q_110a), Brain MRI - Tumor (q_64_2), Spinal cord MRI Cervical - NA (q_65a_8), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• factor variable q_16g, q_24, q_28 and q_30a doesn't have defined level No
• "Housewife" removed in Main Ocupation (q_139), Main Ocupation (q_140), Second Occupation (q_141) and Second Occupation (q_142)
• Neurologist added in First specialist who observed the patient (q_148), Second specialist who observed the patient (q_150), Specialist who made the diagnosis (q_153) and What specialist 1 observed the patient (q_154b_1)
• factor variable q_26 and q_99.c1 doesn't have defined level Yes
• cannot convert value Normal to number in ALSFRS(1) 2. Salivation (q_51_1.2) and ALSFRS(1) 7. Turning in Bed and Adjusting Bed Clothes (q_51_1.7)
• cannot convert value None to number in ALSFRS(1) 11. Orthopnea (q_51_1.11) and ALSFRS(1) 12. Respiratory insufficiency (q_51_1.12)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Father´s birth order (q_108a) and Number of siblings (q_110a2)
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Cervical removed in Region1 (q_49a)
• Lumbo-sacral removed in Region2 (q_49b)
• Thoracic removed in Region3 (q_50a)
• 2017-06-25 added in ALSFRS(1) Acquisition date (q_51_1.date)
• cannot convert value Normal speech processes to number in ALSFRS(1) 1. Speech (q_51_1.1)
• cannot convert value Normal eating habits to number in ALSFRS(1) 3. Swallowing (q_51_1.3)
• cannot convert value Slow or sloppy; all words are legible to number in ALSFRS(1) 4. Handwriting (q_51_1.4)
• cannot convert value Can cut most foods, although clumsy and slow; some help needed to number in ALSFRS(1) 5. Cutting Food and Handling Utensils (q_51_1.5)
• cannot convert value Independent and complete self-care with effort of decreased efficiency to number in ALSFRS(1) 6. Dressing and Hygiene (q_51_1.6)
• cannot convert value Early ambulation difficulties to number in ALSFRS(1) 8. Walking (q_51_1.8)
• cannot convert value Mild unsteadiness or fatigue to number in ALSFRS(1) 9. Climbing Stairs (q_51_1.9)
• cannot convert value Occurs when walking to number in ALSFRS(1) 10. Dyspnea (q_51_1.10)
• 40 removed in ALSFRS-R total (q_51_1.score)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• 5 added in Father´s number of siblings (q_108b)
• 3 added in Siblings' birth order (q_110a1)
• Yes added in Did specialist 1 made diagnosis (q_154d_1)
• "ANTA" removed in centr_id
• 36 replaces value 61 in x

Changes to the patient ANTA-0059

• cannot convert value No to number in 78 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_38.1b, q_38.2a, q_38.2b
• NA added in 71 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• 1 added in 29 questions: Lives in Rural Area/Urban (q_143a), Lives in Rural Area/Urban (q_144a), Brain MRI - Tumor (q_64_2), Brain MRI - Stroke (q_64_3), Brain MRI - Multiple Sclerosis (q_64_4), Brain MRI - Trauma (q_64_5), Brain MRI - Hypoxia (q_64_6), ...Spinal cord MRI Lumbo-sacral - Syringomyelia (q_65c_6), Spinal cord MRI Lumbo-sacral - Other (q_65c_7), Spinal cord MRI Lumbo-sacral - NA (q_65c_8)
• No removed in 20 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_145, q_146, q_147
• 0 added in Cognition - ECAS value (or NF, NA, NR) (q_45a), Cognition - ECAS lower range (q_45b), Cognition - ECAS upper range (q_45c), ALS depression inventory value (or NF, NA, NR) (q_47a), ALS depression inventory upper range (q_47b), ALS depression inventory lower range (q_47c) and Mean number of packs/day (q_88e)
• factor variable q_16g, q_24, q_28 and q_30a doesn't have defined level No
• 2 added in Brain MRI - Normal (q_64_1), Spinal cord MRI Cervical - Normal (q_65a_1), Spinal cord MRI Thoracic - Normal (q_65b_1) and Spinal cord MRI Lumbo-sacral - Normal (q_65c_1)
• factor variable q_26 and q_99.c1 doesn't have defined level Yes
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• No added in Head/Neck trauma in the last 5 years (q_115) and Head/Neck trauma > 5 years (q_116)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• Lower limb replaces value Upper limb in Limb onset (q_18a)
• factor variable Predominant impairment (q_18c) doesn't have defined level Distal
• Cervical removed in Region1 (q_49a)
• Lumbo-sacral removed in Region2 (q_49b)
• 2017-06-25 added in ALSFRS(1) Acquisition date (q_51_1.date)
• NA replaces value NA in ALSFRS(1) Rate of decay (q_51_1.rate)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• Yes replaces value No in q_96a
• "ghj" added in Immunosupressor's name (q_96b)
• Wt/wt (normal) removed in q_97a
• "ANTA" removed in centr_id
• 34 replaces value 59 in x

Changes to the patient ANTC0001

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 15 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_135, q_136, q_138
• 1 added in q_38.1a, q_38.1b, q_38.2a and q_38.2b
• factor variable q_137 and q_99.c1 doesn't have defined level Yes
• 6 added in Mother´s number of siblings (q_107b) and Father´s number of siblings (q_108b)
• "No" removed in Second Occupation (q_141) and Second Occupation (q_142)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• "ANTC0001" replaces value "ANTA0001" in Control subject code (q_3b)
• 2016-01-11 replaces value 2086-01-12 in Date of consultation (q_4)
• 1974-04-23 replaces value 2044-04-24 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 1996 replaces value NA in Year of initiation of smoking (q_88b)
• Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• 5 added in Mother´s birth order (q_107a)
• 4 added in Father´s birth order (q_108a)
• "Housewife" removed in Main Ocupation (q_139)
• "ANTC" removed in centr_id
• 37 replaces value 571 in x

Changes to the patient ANTC0002

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No removed in 19 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_145, q_146, q_147
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• 1 added in Father´s birth order (q_108a), Father´s number of siblings (q_108b), Siblings' birth order (q_110a1), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• "no" removed in Second Occupation (q_141) and Second Occupation (q_142)
• Large town– > 100 000 removed in Place of living (q_143) and Place of living (q_144)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-01-01 replaces value 2086-01-02 in Date of consultation (q_4)
• 1950-04-02 replaces value 2020-04-03 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• Type II replaces value Type I in q_74
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 2 added in Mother´s birth order (q_107a)
• 4 added in Mother´s number of siblings (q_107b)
• 5 added in Number of siblings (q_110a2)
• Yes removed in q_111
• "cook" removed in Main Ocupation (q_139)
• "ANTC" removed in centr_id
• 38 replaces value 572 in x

Changes to the patient ANTC0003

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in Father´s birth order (q_108a), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 7 added in Father´s number of siblings (q_108b) and Number of siblings (q_110a2)
• "Farmer" removed in Main Ocupation (q_140) and Second Occupation (q_141)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-05-26 replaces value 2086-05-28 in Date of consultation (q_4)
• 1959-11-02 replaces value 2029-11-03 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 2 added in Mother´s birth order (q_107a)
• 5 added in Mother´s number of siblings (q_107b)
• 4 added in Siblings' birth order (q_110a1)
• "Housewife" removed in Main Ocupation (q_139)
• "ANTC" removed in centr_id
• 39 replaces value 573 in x

Changes to the patient ANTC0004

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Mother´s number of siblings (q_107b) and Father´s birth order (q_108a)
• cannot convert value Rural area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-05-02 replaces value 2086-05-04 in Date of consultation (q_4)
• 1971-07-21 replaces value 2041-07-22 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 2 added in Mother´s birth order (q_107a)
• 6 added in Father´s number of siblings (q_108b)
• 4 added in Siblings' birth order (q_110a1)
• 8 added in Number of siblings (q_110a2)
• "Housewife" removed in Main Ocupation (q_139)
• "ANTC" removed in centr_id
• 40 replaces value 574 in x

Changes to the patient ANTC0005

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 15 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_135, q_136, q_138
• 1 added in Siblings' birth order (q_110a1), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• 3 added in Mother´s birth order (q_107a), Father´s birth order (q_108a) and Number of siblings (q_110a2)
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• factor variable q_137 and q_99.c1 doesn't have defined level Yes
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-02-01 replaces value 2086-02-02 in Date of consultation (q_4)
• 1968-11-15 replaces value 2038-11-17 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• 8 added in Mother´s number of siblings (q_107b)
• 7 added in Father´s number of siblings (q_108b)
• "Cook" removed in Main Ocupation (q_139)
• "Housewife" removed in Main Ocupation (q_140)
• "ANTC" removed in centr_id
• 41 replaces value 575 in x

Changes to the patient ANTC0006

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in Mother´s birth order (q_107a), Father´s birth order (q_108a), Lives in Rural Area/Urban (q_143a), Lives in Rural Area/Urban (q_144a), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-04-21 replaces value 2086-04-23 in Date of consultation (q_4)
• 1970-01-01 added in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 3 added in Mother´s number of siblings (q_107b)
• 5 added in Father´s number of siblings (q_108b)
• 6 added in Siblings' birth order (q_110a1)
• 7 added in Number of siblings (q_110a2)
• "ANTC" removed in centr_id
• 42 replaces value 576 in x

Changes to the patient ANTC0007

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in Mother´s birth order (q_107a), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 3 added in Father´s birth order (q_108a) and Father´s number of siblings (q_108b)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-01-01 replaces value 2086-01-02 in Date of consultation (q_4)
• 1960-05-01 replaces value 2030-05-03 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 11 added in Mother´s number of siblings (q_107b)
• "Housewife" removed in Main Ocupation (q_139)
• "ANTC" removed in centr_id
• 43 replaces value 577 in x

Changes to the patient ANTC0008

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No removed in 19 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_145, q_146, q_147
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• 1 added in q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Mother´s birth order (q_107a) and Father´s number of siblings (q_108b)
• 2 added in Father´s birth order (q_108a) and Siblings' birth order (q_110a1)
• 3 added in Number of siblings (q_110a2) and How long moderate sport activity 1 (q_112a_1c)
• Large town– > 100 000 removed in Place of living (q_143) and Place of living (q_144)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-02-10 replaces value 2086-02-11 in Date of consultation (q_4)
• 1975-10-03 replaces value 2045-10-04 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 6 added in Mother´s number of siblings (q_107b)
• Fast walking added in Type of moderate sport activity 1 (q_112a_1a)
• "Tourism" removed in Main Ocupation (q_139)
• "Insurer" removed in Main Ocupation (q_140)
• "ANTC" removed in centr_id
• 44 replaces value 578 in x

Changes to the patient ANTC0009

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in Father´s birth order (q_108a), Father´s number of siblings (q_108b), Lives in Rural Area/Urban (q_143a), Lives in Rural Area/Urban (q_144a), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 4 added in Mother´s birth order (q_107a) and Mother´s number of siblings (q_107b)
• 5 added in Siblings' birth order (q_110a1) and Number of siblings (q_110a2)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-02-26 replaces value 2086-02-27 in Date of consultation (q_4)
• 1959-01-01 replaces value 2029-01-02 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• "ANTC" removed in centr_id
• 45 replaces value 579 in x

Changes to the patient ANTC0010

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 24 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 16 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in Siblings' birth order (q_110a1), Lives in Rural Area/Urban (q_143a), Lives in Rural Area/Urban (q_144a), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• Year of initiation of smoking (q_88b) and Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 5 added in Mother´s birth order (q_107a) and Number of siblings (q_110a2)
• 4 added in Father´s number of siblings (q_108b) and Number of children (q_110a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-08-12 replaces value 2086-08-14 in Date of consultation (q_4)
• 1974-05-04 replaces value 2044-05-05 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• factor variable q_99.c1 doesn't have defined level Yes
• 10 added in Mother´s number of siblings (q_107b)
• 3 added in Father´s birth order (q_108a)
• "ANTC" removed in centr_id
• 46 replaces value 580 in x

Changes to the patient ANTC0011

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 23 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• No removed in 14 questions: q_123, q_124, q_125, q_126, q_127, q_128, q_129, ...q_136, q_137, q_138
• 1 added in Father´s birth order (q_108a), Siblings' birth order (q_110a1), q_38.1a, q_38.1b, q_38.2a and q_38.2b
• factor variable q_133, q_134 and q_99.c1 doesn't have defined level Yes
• 2 added in Mother´s birth order (q_107a) and Father´s number of siblings (q_108b)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2016-03-11 replaces value 2086-03-13 in Date of consultation (q_4)
• 1979-01-18 replaces value 2049-01-19 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• 2 replaces value NA in Year of initiation of smoking (q_88b)
• Year of interruption of smoking (q_88d) doesn't allow for tagged NA 2
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• 9 added in Mother´s number of siblings (q_107b)
• 4 added in Number of siblings (q_110a2)
• cannot convert value Yes to number in q_121a
• "Tourism" removed in Main Ocupation (q_139)
• "No" removed in Second Occupation (q_141)
• "ANTC" removed in centr_id
• 47 replaces value 581 in x

Changes to the patient ANTC0012

• NA added in 152 questions: Regular specific diet - No (q_114a), Regular specific diet - Mediterranean (q_114b), Regular specific diet - Vegetarian (q_114c), Regular specific diet - Vegan (q_114d), Regular specific diet - Gluten-free (q_114e), Regular specific diet - High protein (q_114f), Regular specific diet - Low carbohydrate (q_114g), ...Metastasis - Colon (q_85b_7), Metastasis - Rectum (q_85b_8), Metastasis - other Abdominal (q_85b_9)
• cannot convert value No to number in 22 questions: q_117a, q_117b, q_117c, q_118a, q_118b, q_118c, q_119a, ...q_144c, q_144d, q_144e
• No removed in 19 questions: q_110d, q_123, q_124, q_125, q_126, q_127, q_128, ...q_145, q_146, q_147
• No added in 16 questions: Head/Neck trauma in the last 5 years (q_115), Head/Neck trauma > 5 years (q_116), q_19, q_20, q_21, q_30, q_31, ...q_40, q_41, q_63
• 1 added in q_38.1a, q_38.1b, q_38.2a and q_38.2b
• factor variable q_133 and q_99.c1 doesn't have defined level Yes
• cannot convert value Yes to number in q_120b and q_120c
• "Technician" removed in Main Ocupation (q_139) and Second Occupation (q_141)
• Large town– > 100 000 removed in Place of living (q_143) and Place of living (q_144)
• cannot convert value Urban area to number in Lives in Rural Area/Urban (q_143a) and Lives in Rural Area/Urban (q_144a)
• Antalya added in Medical facility (facility_id)
• Hilmi Uysal added in Physician recording the data (person_id)
• 2017-01-12 replaces value 2087-01-14 in Date of consultation (q_4)
• 1967-01-01 replaces value 2037-01-02 in Date of birth (q_5)
• factor variable Ethinicity (q_7) doesn't have defined level Caucassian
• None added in Which cognitive symptoms at onset (q_22)
• Right added in Handedness (q_23)
• Positive added in q_43
• Type II replaces value Type I in q_74
• Year of initiation of smoking (q_88b) doesn't allow for tagged NA 2
• 0 added in Mean number of packs/day (q_88e)
• 2018-02-20 added in Date of initiation of Riluzole (q_91b)
• "ANTC" removed in centr_id
• 48 replaces value 582 in x

Changes to data structure and layout when transforming df1 into df2

The paragraph below shows differences in data layout between the datasets

Changes to the question property Variable name

• "" replaces value "Place of living" for q_143 and q_144
• "" replaces value "Lives in Rural Area/Urban" for q_143a and q_144a
• "" replaces value "Medical facility" for facility_id
• "" replaces value "Physician recording the data" for person_id
• "Familial history of ALS" replaces value "How many family members 1 had a history of ALS" for q_100a_2
• "Familial history of ALS" replaces value "How many family members 2 had a history of ALS" for q_100b_2
• "Familial history of ALS" replaces value "How many family members 3 had a history of ALS" for q_100c_2
• "Familial history of FTD" replaces value "How many family members 1 had a history of FTD" for q_101a_2
• "Familial history of FTD" replaces value "How many family members 2 had a history of FTD" for q_101b_2
• "Familial history of FTD" replaces value "How many family members 3 had a history of FTD" for q_101c_2
• "Familial history of Alzheimer disease" replaces value "How many family members 1 had a history of Alzheimer disease" for q_102a_2
• "Familial history of Alzheimer disease" replaces value "How many family members 2 had a history of Alzheimer disease" for q_102b_2
• "Familial history of Alzheimer disease" replaces value "How many family members 3 had a history of Alzheimer disease" for q_102c_2
• "Familial history of Parkinson disease" replaces value "How many family members 1 had a history of Parkinson disease" for q_103a_2
• "Family history of multiple sclerosis" replaces value "How many family members 1 had a history of multiple scrlerosis" for q_104a_2
• "Family history of multiple sclerosis" replaces value "How many family members 2 had a history of multiple scrlerosis" for q_104b_2
• "Parents’ and siblings´ causes of death" replaces value "Age of family member 1 at the moment of death" for q_106_1d
• "Parents’ and siblings´ causes of death" replaces value "Age of family member 2 at the moment of death" for q_106_2d
• "Parents’ and siblings´ causes of death" replaces value "Age of family member 3 at the moment of death" for q_106_3d
• "Parents’ and siblings´ causes of death" replaces value "Age of family member 4 at the moment of death" for q_106_4d
• "Mother´s number of siblings and birth order" replaces value "Mother´s birth order" for q_107a
• "Mother´s number of siblings and birth order" replaces value "Mother´s number of siblings" for q_107b
• "Father´s number of siblings and birth order" replaces value "Father´s birth order" for q_108a
• "Father´s number of siblings and birth order" replaces value "Father´s number of siblings" for q_108b
• "" replaces value "Father's Place of birth" for q_10a
• "" replaces value "Father's Place of birth characteristics" for q_10b
• "" replaces value "Date of 1st Symptoms" for q_11
• "Number of siblings and birth order" replaces value "Siblings' birth order" for q_110a1
• "Number of siblings and birth order" replaces value "Number of siblings" for q_110a2
• "Moderate aerobic activity (such as fast walking, swimming) >150 min/week" replaces value "How long moderate sport activity 1" for q_112a_1c
• "Moderate aerobic activity (such as fast walking, swimming) >150 min/week" replaces value "How long moderate sport activity 2" for q_112a_2c
• "Moderate aerobic activity (such as fast walking, swimming) >150 min/week" replaces value "How long moderate sport activity 3" for q_112a_3c
• "Moderate aerobic activity (such as fast walking, swimming) >150 min/week" replaces value "How long moderate sport activity 4" for q_112a_4c
• "Vigorous aerobic activity (such as running or aerobic dancing) >75 min/week" replaces value "How long vigorous sport activity 1" for q_112b_1c
• "Vigorous aerobic activity (such as running or aerobic dancing) >75 min/week" replaces value "How long vigorous sport activity 2" for q_112b_2c
• "Vigorous aerobic activity (such as running or aerobic dancing) >75 min/week" replaces value "How long vigorous sport activity 3" for q_112b_3c
• "Mild physical exercise <75 min/week, >1 year" replaces value "How long mild sport activity 1" for q_113_1c
• "Mild physical exercise <75 min/week, >1 year" replaces value "How long mild sport activity 2" for q_113_2c
• "" replaces value "Regular specific diet - No" for q_114a
• "" replaces value "Regular specific diet - Mediterranean" for q_114b
• "" replaces value "Regular specific diet - Vegetarian" for q_114c
• "" replaces value "Regular specific diet - Vegan" for q_114d
• "" replaces value "Regular specific diet - Gluten-free" for q_114e
• "" replaces value "Regular specific diet - High protein" for q_114f
• "" replaces value "Regular specific diet - Low carbohydrate" for q_114g
• "" replaces value "Regular specific diet - Paleo (High-protein, high-fat, low-carbohydrate)" for q_114h
• "" replaces value "Date of 1st Medical Consultation" for q_12
• "" replaces value "Date of Diagnosis" for q_13
• "" replaces value "Date of Invasive ventilation" for q_14
• "" replaces value "Date of Death" for q_15
• "Time gap between first-second specialist (months)" replaces value "Time gap between first-second specialist" for q_151
• "Order of specialists that observed the patient" replaces value "Order of specialist 1 that observed the patient" for q_154a_1
• "Order of specialists that observed the patient" replaces value "Order of specialist 2 that observed the patient" for q_154a_2
• "Order of specialists that observed the patient" replaces value "Order of specialist 3 that observed the patient" for q_154a_3
• "Order of specialists that observed the patient" replaces value "Order of specialist 4 that observed the patient" for q_154a_4
• "Order of specialists that observed the patient" replaces value "Order of specialist 5 that observed the patient" for q_154a_5
• "Order of specialists that observed the patient" replaces value "Order of specialist 6 that observed the patient" for q_154a_6
• "Order of specialists that observed the patient" replaces value "Order of specialist 7 that observed the patient" for q_154a_7
• "Order of specialists that observed the patient" replaces value "Other type of specialist 7 that observed the patient" for q_154c_7
• "" replaces value "Did specialist 1 made diagnosis" for q_154d_1
• "" replaces value "Did specialist 2 made diagnosis" for q_154d_2
• "" replaces value "Did specialist 3 made diagnosis" for q_154d_3
• "" replaces value "Did specialist 4 made diagnosis" for q_154d_4
• "" replaces value "Did specialist 5 made diagnosis" for q_154d_5
• "" replaces value "Did specialist 6 made diagnosis" for q_154d_6
• "" replaces value "Did specialist 7 made diagnosis" for q_154d_7
• "Time gap between first medical observation and the specialist who made the diagnosis (months)" replaces value "Time gap between first medical observation and diagnosis" for q_155
• "Generalized onset" replaces value "" for q_16g
• "" replaces value "UMN vs LMN manifestation at onset" for q_17
• "" replaces value "Limb onset" for q_18a
• "" replaces value "Predominant side" for q_18b
• "" replaces value "Which cognitive symptoms at onset" for q_22
• "" replaces value "Handedness" for q_23
• "Bulbar region" replaces value "" for q_24
• "Upper Limbs" replaces value "" for q_26
• "Lower Limbs" replaces value "" for q_28
• "Axial muscles" replaces value "" for q_30a
• "" replaces value "Alternative diagnosis" for q_36b
• "" replaces value "Sensory changes" for q_39
• "" replaces value "Date of consultation" for q_4
• "Postural instability - NURT" replaces value "" for q_42
• "" replaces value "Cognition - Qualitative evaluation" for q_44
• "Cognition – ECAS observed value (normal range)" replaces value "Cognition - ECAS value (or NF, NA, NR)" for q_45a
• "Cognition – ECAS observed value (normal range)" replaces value "Cognition - ECAS lower range" for q_45b
• "Cognition – ECAS observed value (normal range)" replaces value "Cognition - ECAS upper range" for q_45c
• "" replaces value "Depression - Qualitative evaluation" for q_46
• "Depression - ALS depression inventory" replaces value "ALS depression inventory value (or NF, NA, NR)" for q_47a
• "Depression - ALS depression inventory" replaces value "ALS depression inventory upper range" for q_47b
• "Depression - ALS depression inventory" replaces value "ALS depression inventory lower range" for q_47c
• "Timing of transition from region 1 to 2 (months)" replaces value "Timing of transition from region 1 to 2" for q_49c
• "" replaces value "Date of birth" for q_5
• "Timing of transition from region 2 to 3 (months)" replaces value "Timing of transition from region 2 to 3" for q_50b
• "" replaces value "ALSFRS(1) Acquisition date" for q_51_1.date
• "ALSFRS(1) Score" replaces value "ALSFRS-R total" for q_51_1.score
• "" replaces value "ALSFRS(2) Acquisition date" for q_51_2.date
• "ALSFRS-R history" replaces value "ALSFRS-R take 2 total" for q_51_2.score
• "" replaces value "Gender" for q_6
• "" replaces value "Brain MRI - Normal" for q_64_1
• "" replaces value "Brain MRI - Tumor" for q_64_2
• "" replaces value "Brain MRI - Stroke" for q_64_3
• "" replaces value "Brain MRI - Multiple Sclerosis" for q_64_4
• "" replaces value "Brain MRI - Trauma" for q_64_5
• "" replaces value "Brain MRI - Hypoxia" for q_64_6
• "" replaces value "Brain MRI - NA" for q_64_7
• "" replaces value "Spinal cord MRI Cervical - Normal" for q_65a_1
• "" replaces value "Spinal cord MRI Cervical - Tumor" for q_65a_2
• "" replaces value "Spinal cord MRI Cervical - Stenosis" for q_65a_3
• "" replaces value "Spinal cord MRI Cervical - Myelitis" for q_65a_4
• "" replaces value "Spinal cord MRI Cervical - Trauma" for q_65a_5
• "" replaces value "Spinal cord MRI Cervical - Syringomyelia" for q_65a_6
• "" replaces value "Spinal cord MRI Cervical - Other" for q_65a_7
• "" replaces value "Spinal cord MRI Cervical - NA" for q_65a_8
• "" replaces value "Spinal cord MRI Thoracic - Normal" for q_65b_1
• "" replaces value "Spinal cord MRI Thoracic - Tumor" for q_65b_2
• "" replaces value "Spinal cord MRI Thoracic - Stenosis" for q_65b_3
• "" replaces value "Spinal cord MRI Thoracic - Myelitis" for q_65b_4
• "" replaces value "Spinal cord MRI Thoracic - Trauma" for q_65b_5
• "" replaces value "Spinal cord MRI Thoracic - Syringomyelia" for q_65b_6
• "" replaces value "Spinal cord MRI Thoracic - Other" for q_65b_7
• "" replaces value "Spinal cord MRI Thoracic - NA" for q_65b_8
• "" replaces value "Spinal cord MRI Lumbo-sacral - Normal" for q_65c_1
• "" replaces value "Spinal cord MRI Lumbo-sacral - Tumor" for q_65c_2
• "" replaces value "Spinal cord MRI Lumbo-sacral - Stenosis" for q_65c_3
• "" replaces value "Spinal cord MRI Lumbo-sacral - Myelitis" for q_65c_4
• "" replaces value "Spinal cord MRI Lumbo-sacral - Trauma" for q_65c_5
• "" replaces value "Spinal cord MRI Lumbo-sacral - Syringomyelia" for q_65c_6
• "" replaces value "Spinal cord MRI Lumbo-sacral - Other" for q_65c_7
• "" replaces value "Spinal cord MRI Lumbo-sacral - NA" for q_65c_8
• "" replaces value "Ethinicity" for q_7
• "Diabetes – type I / II" replaces value "" for q_74
• "" replaces value "Primary cancer - Brain" for q_85a_1
• "" replaces value "Primary cancer - Prostate" for q_85a_10
• "" replaces value "Primary cancer - Uterus" for q_85a_11
• "" replaces value "Primary cancer - other Plevic" for q_85a_12
• "" replaces value "Primary cancer - Spine" for q_85a_13
• "" replaces value "Primary cancer - UL bone & sarcomas" for q_85a_14
• "" replaces value "Primary cancer - LL bone & sarcomas" for q_85a_15
• "" replaces value "Primary cancer - Skin" for q_85a_16
• "" replaces value "Primary cancer - Leukemia" for q_85a_17
• "" replaces value "Primary cancer - Lymphoma" for q_85a_18
• "" replaces value "Primary cancer - other Blood" for q_85a_19
• "" replaces value "Primary cancer - Neck" for q_85a_2
• "" replaces value "Primary cancer - Breast" for q_85a_3
• "" replaces value "Primary cancer - Lung" for q_85a_4
• "" replaces value "Primary cancer - other Thoracic" for q_85a_5
• "" replaces value "Primary cancer - Gastric" for q_85a_6
• "" replaces value "Primary cancer - Colon" for q_85a_7
• "" replaces value "Primary cancer - Rectum" for q_85a_8
• "" replaces value "Primary cancer - other Abdominal" for q_85a_9
• "" replaces value "Metastasis - Brain" for q_85b_1
• "" replaces value "Metastasis - Prostate" for q_85b_10
• "" replaces value "Metastasis - Uterus" for q_85b_11
• "" replaces value "Metastasis - other Plevic" for q_85b_12
• "" replaces value "Metastasis - Spine" for q_85b_13
• "" replaces value "Metastasis - UL bone & sarcomas" for q_85b_14
• "" replaces value "Metastasis - LL bone & sarcomas" for q_85b_15
• "" replaces value "Metastasis - Skin" for q_85b_16
• "" replaces value "Metastasis - Leukemia" for q_85b_17
• "" replaces value "Metastasis - Lymphoma" for q_85b_18
• "" replaces value "Metastasis - other Blood" for q_85b_19
• "" replaces value "Metastasis - Neck" for q_85b_2
• "" replaces value "Metastasis - Breast" for q_85b_3
• "" replaces value "Metastasis - Lung" for q_85b_4
• "" replaces value "Metastasis - other Thoracic" for q_85b_5
• "" replaces value "Metastasis - Gastric" for q_85b_6
• "" replaces value "Metastasis - Colon" for q_85b_7
• "" replaces value "Metastasis - Rectum" for q_85b_8
• "" replaces value "Metastasis - other Abdominal" for q_85b_9
• "Date of initiation of smoking (year)" replaces value "Year of initiation of smoking" for q_88b
• "Date of interruption of smoking (year)" replaces value "Year of interruption of smoking" for q_88d
• "" replaces value "Place of birth" for q_8a
• "" replaces value "Place of birth characteristics" for q_8b
• "" replaces value "Date of initiation of Riluzole" for q_91b
• "" replaces value "Abnormal C9orf72 repeat-expansion" for q_98_1
• "" replaces value "TBK1 mutation" for q_98_2a
• "" replaces value "Other gene 1" for q_99.a1
• "" replaces value "Other gene 2" for q_99.a2
• "Was the patient included in other genomic studies" replaces value "" for q_99.c1
• "" replaces value "Mother's Place of birth" for q_9a
• "" replaces value "Mother's Place of birth characteristics" for q_9b

Changes to the question property Variable labels dictionary

• "" replaces value "1="No";2="Yes"" for 155 questions: q_114a, q_114b, q_114c, q_114d, q_114e, q_114f, q_114g, ...q_85b_7, q_85b_8, q_85b_9
• "" replaces value "NA(c)="NR";NA(a)="NA";NA(b)="NF"" for q_88b, q_88d and q_88e
• "" replaces value "1="Rural area";2="Urban area"" for q_143a and q_144a
• "" replaces value "NA(a)="NA";NA(d)="unknown"" for q_49c and q_50b
• "" replaces value "0="Loss of useful speech";1="Speech combined with nonvocal communication";2="Intelligible with repeating";3="Detectable speech disturbances";4="Normal speech processes"" for q_51_1.1 and q_51_2.1
• "" replaces value "0="Significant difficulty, considering using mechanical respiratory support";1="Occurs at rest Shortness of breath at rest, difficulty breathing when either sitting or lying";2="Occurs with >= 1 of the following: eating, bathing, dressing (ADL)";3="Occurs when walking";4="None"" for q_51_1.10 and q_51_2.10
• "" replaces value "0="Unable to sleep";1="Can only sleep sitting up";2="Needs extra pillows in order to sleep (>2)";3="Some difficulty sleeping at night due to shortness of breath (does not routinely use more than two pillows)";4="None"" for q_51_1.11 and q_51_2.11
• "" replaces value "0="Invasive mechanical ventilation by intubation or tracheostomy";1="Continuous use of BiPAP during the night and day";2="Continuous use of BiPAP during the night";3="Intermittent use of BiPAP";4="None"" for q_51_1.12 and q_51_2.12
• "" replaces value "0="Marked drooling; requires constant tissue or handkerchief";1="Marked excess of saliva with some drooling";2="Moderately excessive saliva; may have minimal drooling";3="Slight but definite excess of saliva in mouth; may have nightime drooling";4="Normal"" for q_51_1.2 and q_51_2.2
• "" replaces value "0="NPO (exclus. parenteral or enteral feeding)";1="Needs supplemental tube feeding";2="Dietary consistency changes";3="Early eating problems - occasional choking";4="Normal eating habits"" for q_51_1.3 and q_51_2.3
• "" replaces value "0="Unable to grip pen";1="Able to grip pen but unable to write";2="Not all words are legible";3="Slow or sloppy; all words are legible";4="Normal"" for q_51_1.4 and q_51_2.4
• "" replaces value "0="Needs to be fed";1="Food must be cut by someone, but can still feed slowly";2="Can cut most foods, although clumsy and slow; some help needed";3="Somewhat slow and clumsy, but no help needed";4="Normal"" for q_51_1.5 and q_51_2.5
• "" replaces value "0="Total dependence";1="Needs attendant for self-care";2="Intermittent assistance or substitute methods";3="Independent and complete self-care with effort of decreased efficiency";4="Normal function"" for q_51_1.6 and q_51_2.6
• "" replaces value "0="Helpless";1="Can initiate, but not turn or adjust sheets alone";2="Can turn alone or adjust sheets, but with great difficulty";3="Somewhat slow and clumsy, but no help needed";4="Normal"" for q_51_1.7 and q_51_2.7
• "" replaces value "0="No purposeful leg movement";1="Nonambulatory functional movement";2="Walks with assistance";3="Early ambulation difficulties";4="Normal"" for q_51_1.8 and q_51_2.8
• "" replaces value "0="Cannot do";1="Needs assistance";2="Mild unsteadiness or fatigue";3="Slow";4="Normal"" for q_51_1.9 and q_51_2.9
• "1="Antalya";2="Hannover";3="Jena";4="Lisbon";5="Pisa";6="Warsaw"" replaces value "" for facility_id
• "1="Annalisa Logerfo";2="B Stubbendorf";3="Hilmi Uysal";4="K Szacka";5="Mamede de Carvalho";6="Susanne Petri-Mals"" replaces value "" for person_id
• "" replaces value "NA(a)="NA";NA(b)="NF";NA(c)="NR"" for q_151
• "" replaces value "NA(a)="NA";NA(b)="NF"" for q_155
• "1="No answer required for this field"" replaces value "1="No answer required for this field";2="NA"" for q_156
• "" replaces value "1="Positive";2="Negative";NA(b)="Positive";NA(b)="Negative"" for q_42
• "1="No";2="Head";3="Neck";4="Head and neck"" replaces value "1="No";2="Head";3="Neck";4="Head and neck";5="NA";6="Yes"" for q_87b

Changes to the question property class

• integer replaces value nominal for 157 questions: q_114a, q_114b, q_114c, q_114d, q_114e, q_114f, q_114g, ...q_85b_7, q_85b_8, q_85b_9
• integer added for 45 questions: q_100a_2, q_100b_2, q_100c_2, q_100d_2, q_101a_2, q_101b_2, q_101c_2, ...q_47c, q_51_2.score, x
• integer replaces value labelled for 24 questions: q_51_1.1, q_51_1.10, q_51_1.11, q_51_1.12, q_51_1.2, q_51_1.3, q_51_1.4, ...q_51_2.7, q_51_2.8, q_51_2.9
• integer replaces value real number for 17 questions: q_107a, q_107b, q_108a, q_108b, q_110a1, q_110a2, q_112a_1c, ...q_88b, q_88d, q_88e
• nominal replaces value text for facility_id and person_id
• integer replaces value text for q_154c_7
• real number added for q_51_1.score

Other items

• NA removed in Theoretical min for q_4 and q_5
• NA added in Theoretical min for q_51_1.score

• "F" added in measure_type for q_16g, q_24, q_26, q_28, q_30a, q_74 and q_99.c1
• "I" added in measure_type for q_51_1.score

• FALSE replaces value TRUE in Force only values that are labelled for 168 questions: q_11, q_114a, q_114b, q_114c, q_114d, q_114e, q_114f, ...q_85b_7, q_85b_8, q_85b_9
• TRUE replaces value FALSE in Force only values that are labelled for facility_id, person_id and q_51_1.score

• "FALSE" added in Force only integral values for q_74

• NA removed in Theoretical max for q_4 and q_5

• "FALSE" replaces value "1" in Force only non-missing values for facility_id, person_id, q_11, q_13, q_4, q_5, q_6 and q_7

• 0 removed in warnings_context for 14 questions: facility_id, person_id, q_107a, q_107b, q_108a, q_108b, q_110a1, ...q_113_1c, q_151, q_155

adamryczkowski/ONWebDUALSimport documentation built on Dec. 6, 2018, 2:09 p.m.