ahwbest/DR4PL: Dose Response Data Analysis using the 4 Parameter Logistic (4PL) Model

This R package models the relationship between dose levels and responses in pharmacological and toxicological experiments using the 4 Parameter Logistic (4PL) model. Traditional R packages on dose-response modelling such as drc and nplr often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical theory. As remedies to convergence failure problems, this R package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes.

Getting started

Package details

Maintainer
LicenseGPL
Version1.0.0
URL https://github.com/ahwbest/dr4pl
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("ahwbest/DR4PL")
ahwbest/DR4PL documentation built on Oct. 20, 2017, 5:18 a.m.