FindHillBounds: Compute the Hill bounds based on initial parameter estimates...

In ahwbest/dr4pl: Dose Response Data Analysis using the 4 Parameter Logistic (4PL) Model

Description

Compute the Hill bounds based on initial parameter estimates and data.

Usage

FindHillBounds(x, y, theta, use.Hessian = FALSE, level = 0.9999)

Arguments

x	Vector of doses.
y	Vector of responses.
theta	Parameters of a 4PL model.
use.Hessian	Indicator of whether the Hessian matrix (TRUE) or the gradient vector is used in confidence interval computation.
level	Confidence level to be used in computing the Hill bounds.

Details

This function computes the Hill bounds based on initial parameter estimates and data. It basically computes the confidence intervals of the true parameters based on the variance-covariance matrix of a given initial parameter estimates. The half of a hessian matrix is used as a variance-covariance matrix. If matrix inversion of the variance-covariance matrix is infeasible, a variation of the method in Wang et al. (2010) is used. The parameter level is only for simulation.

Value

Data frame whose first column represents the bounds on the IC50 parameter in log 10 scale and second column represents the bounds on the slope parameter.

Author(s)

Hyowon An

References

\insertRef

Higham2002dr4pl \insertRefWang2010dr4pl

See Also

FindInitialParms

ahwbest/dr4pl documentation built on May 30, 2019, 4:20 p.m.