meld: Calculate MELD scores

In ampel-leipzig/ameld: Data and Model of End-Stage Liver Disease used in the AMPEL Project

Calculate MELD scores

Description

Calculate MELD, MELD-Na scores and MELD or MELD-Plus score based survival probabilities.

Usage

meld(
  creatinine,
  bilirubin,
  inr,
  dialysis = FALSE,
  cause = "other",
  round = FALSE
)

meld_na(
  creatinine,
  bilirubin,
  inr,
  sodium,
  dialysis = FALSE,
  type = c("kim2008", "unos"),
  cause = "other",
  round = FALSE
)

meld3(
  creatinine,
  bilirubin,
  inr,
  sodium,
  albumin,
  female = TRUE,
  round = FALSE
)

pmeld(
  meld = NULL,
  creatinine,
  bilirubin,
  inr,
  dialysis = FALSE,
  cause = "other"
)

pmeld3(meld = NULL, creatinine, bilirubin, inr, sodium, albumin, female)

pmeld_plus7(
  creatinine,
  bilirubin,
  inr,
  sodium,
  albumin,
  wbc,
  age,
  round = FALSE
)

Arguments

creatinine	numeric, [mg/dl]
bilirubin	numeric, [mg/dl]
inr	numeric
dialysis	logical, had dialysis twice, or 24 hours of CVVHD, within a week prior to the serum creatinine test?
cause	character, cause of cirrhosis. Has to be of the same length as creatinine, bilirubin, inr and dialysis. Just "ethyltoxic", "cholestatic", "unos" and "other" are supported. Use "unos" for the United Network for Organ Sharing definition of the score.
round	logical, round to nearest integer?
sodium	numeric, [mmol/l]
type	character(1), type of implementation
albumin	numeric, [g/dl]
female	logical
meld	numeric, MELD/MELD-Na score as calculated by meld or meld-na.
wbc	numeric, [Gpt/l]
age	numeric, [years]

Details

Laboratory values (creatinine, bilirubin, INR) below 1.0 are set to 1.0 and creatinine above 4.0 is set to 4.0 as described in Wiesner et al. 2003.

The original MELD-Plus risk score reports a mortality probability. To provide a common interface with pmeld pmeld_plus7 returns a survival probabilitiy instead.

Value

numeric, MELD or MELD-Na score for meld and meld_na respectively. pmeld and pmeld_plus7 return the survival probability based on the MELD and MELD-Plus7 score.

References

Michael Malinchoc et al. 2000. "A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts" Hepatology 31 (4): 864-871. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1053/he.2000.5852")}

United Network for Organ Sharing (UNOS). Policy notice 11/2015: OPTN executive committee actions. Available at: https://optn.transplant.hrsa.gov/media/1575/policynotice_20151101.pdf Accessed: September 11, 2019.

Kim et al. 2008. "Hyponatremia and Mortality among Patients on the Liver-Transplant Waiting List" N Engl J Med 2008; 359: 1018-1026 \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1056/NEJMoa0801209")}

Kim et al. 2021. "MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era" Gastroenterology 2021; 161: 1887-1895.e4 \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1053/j.gastro.2021.08.050")}

Wiesner et al. 2003. "Model for end-stage liver disease (MELD) and allocation of donor livers" Gastroentrology, 124 (1): 91-96 \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1053/gast.2003.50016")}

Kartoun et al. 2017. "The MELD-Plus: A generalizable prediction risk score in cirrhosis" PloS one, 12 (10): e0186301 \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1371/journal.pone.0186301")}

Examples

meld(creatinine = 1.9, bilirubin = 4.2, inr = 1.2, cause = "other")

meld_na(creatinine = 1.9, bilirubin = 4.2, inr = 1.2, sodium = 135)
meld_na(creatinine = 1.9, bilirubin = 4.2, inr = 1.2, sodium = 135,
        type = "unos")

meld3(creatinine = 1.9, bilirubin = 4.2, inr = 1.2, sodium = 135, albumin = 3.5)

pmeld(creatinine = 1.9, bilirubin = 4.2, inr = 1.2, cause = "other")
pmeld(meld = 20)

pmeld3(meld = 20)

pmeld_plus7(2.5, 4.1, 1.2, 137, 24, 6.7, 56)

ampel-leipzig/ameld documentation built on Aug. 23, 2024, 7:31 p.m.