gwasFast: Fast Simulation of GWAS Summary Statistics
In andreyshabalin/simPRS: Fast Simulation of Polygenic Risk Scores

Description Usage Arguments Details Value Author(s) Examples

Generates estimates of SNP effect sizes and p-values based on the true effect sizes and samples size.

1	gwasFast(signal, N)

`signal`	Vector of effect sizes for all SNPs. Can be generated with `genSignal`.
`N`	GWAS sample size.

The function does not generate the artificial genotype and phenotype. Instead, finite sample distribution of the summary statistics is used for generation of the output.

The function generates vectors of estimates of SNP effect sizes beta and p-values pv.
The vectors have the same length as signal.

Andrey A Shabalin andrey.shabalin@gmail.com

signal = genSignal(
            NSignalSnps = 10,
            NTotalSNPs = 20,
            heritability = 0.1,
            signalDistr = "Same")
            
gwas = gwasFast(signal = signal, N = 100)

cbind(beta = gwas$beta, pv = gwas$pv)