MatrixPropagation: Propagation of the phenotypic score within of a multilayer...

In aschluter/ClinPrior: Disease Gene prioritization

Propagation of the phenotypic score within of a multilayer network with physical and functional interactions

Description

Propagation of the phenotypic score within of a multilayer network with physical and functional interactions

Usage

MatrixPropagation(Y, alpha = 0.2)

Arguments

Y	vector with the phenotypic score obtained from the proteinScore function.
alpha	numeric value [0-1] that ponderates the propagation (alpha) and the previous knowledge (Y) (1-alpha) contribution in the final phenotypic score in the iterative propagation process.

Value

matrix with final phenotypic scores after iterative propagation in a physical protein-protein interaction network and in a functional one.

Examples

HPOpatient = c("HP:0004481","HP:0002376","HP:0001257","HP:0001250","HP:0000238","HP:0002922","HP:0000365")
Y<-proteinScore(HPOpatient)
ClinPriorGeneScore<-MatrixPropagation(Y,alpha=0.2)

aschluter/ClinPrior documentation built on Sept. 27, 2024, 3:46 a.m.