gwas_power: Calculate power for GWAS of a binary trait

In benjacobs123456/popPoweR: Power analysis for replication GWAS in other ancestries.

Calculate power for GWAS of a binary trait

Description

Calculate power for GWAS of a binary trait

Usage

gwas_power(
  eaf = 0.5,
  beta_alt = 0.5,
  n_case = 1000,
  n_control = 1000,
  alpha = 5e-08,
  n_perm = 1000
)

Arguments

eaf	effect allele frequency
beta_alt	beta under the alternate hypothesis (i.e. per-allele log odds ratio in your discovery GWAS)
n_case	number of cases
n_control	number of controls
alpha	desired alpha
n_perm	number of permutations for power calculations

Value

the estimated power for each SNP given the allele frequency, n, alpha, effect size, and number of permutations. Note that this is for a one-tailed test.

benjacobs123456/popPoweR documentation built on March 28, 2022, 4:32 a.m.