as.NONMEMdata: Convert a PKNCA object into a NONMEM-ready dataset

In billdenney/pknca.portation: Import and Export Data from PKNCA Using Data Standards

Description

Convert a PKNCA object into a NONMEM-ready dataset

Usage

as.NONMEMdata(object, ...)

## S3 method for class 'PKNCAdata'
as.NONMEMdata(object, ..., conc_cmt_map, dose_cmt_map)

## S3 method for class 'PKNCAconc'
as.NONMEMdata(object, ..., conc_cmt_map = NULL)

## S3 method for class 'PKNCAdose'
as.NONMEMdata(object, ..., dose_cmt_map = NULL)

Arguments

object	The object to make into a NONMEM-ready dataset. To ensure consistent output of reset data, it's preferred to provide a PKNCAdata object.
...	Ignored
conc_cmt_map, dose_cmt_map	A data.frame (or similar object) that indicates the mapping between concentration or dosing data and compartment names. See details for more information.

Details

The attribute "NONMEM_column" will be added to columns to define the following.

For every data type:

• IDthe PKNCA subject

• TIMEthe time (right hand side) column

• EVID0 for PKNCAconc, 1 for PKNCAdose, 3 for reset

• EXCLUDETEXTthe text of the exclude column; this will be converted to a factor and put into the EXCLUDENUM column on conversion to a data.frame (and writing to a file)

For concentration data, name mapping for every data type plus:

• DVconcentration measurement (or generally, the independent variable for PKNCAconc

For dose data, name mapping for every data type plus:

• AMTamount of the dose for PKNCAdose

• RATEthe rate of dosing for PKNCAdose

• IIinterdose interval is set to 0

• ADDLadditional dose count is set to 0

conc_cmt_map and dose_cmt_map will use the dplyr::left_join function to combine with the data, so matching columns will define the mapping. One column must be named "CMT" in the data.frame.

Value

A data.frame or similar ready for export to a .csv file as a NONMEM-ready dataset with an attribute "name_map" for mapping the data.frame names to NONMEM names.

Methods (by class)

• PKNCAdata: Convert a PKNCAdata object to NONMEM data

• PKNCAconc: Convert a PKNCAconc object to NONMEM data

• PKNCAdose: Convert a PKNCAdose object to NONMEM data

billdenney/pknca.portation documentation built on May 3, 2019, 2:55 p.m.