In brouwern/shroom: Example Analyses for Cell and Molecular Biology

knitr::opts_chunk$set(
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Put intro material here : )

Candidate proteins that interact with other proteins/enzygmes

able

• Tyrosine kinase.
• Phosphorylates other proteins and regualtes their activity (including trio).
• activates trio (a GTP exchange factor)
• Regulates actin architecture
• Oncogene (BCR-Able)
• targeted by Glivec, one of the few targeted molecular medicines
• Knocking out able on its own results in neural tube defects, similar to knocking out shroom

trio

• GTP Exchange factor (GEF)
• Trio activates Rho (Rock?)
• Rho is a GTPase
• Shroom binds Rock, Rock activates myosin
• regulated by able
• Trio is upregulated in human cancers; involved in cell adhesion/migration

ssh (slingshot)

• phosphotase
• activates tws (twinstar) which is an actin depolymerizer

Candidates which interact directly with actin

fhos

• Formin
• regulates actin filaments
• multiple Fhos genes
• no known medical implications (yet?)

dia (diaphanous)

• formin
• Actin polymerizer (actin nucleator)
• activated by GTPases
• Human health/biology: inner ear: actin structures with hairs

tws (twinstar)

• actin de-polymerizer
• vertebrates: cofilin
• might reduce the amount of actin; OR, by createing free ens cause bursts of actin synthesis!

brouwern/shroom documentation built on May 24, 2019, 7:54 a.m.