hamilton: Example dose-response curves from Hamilton (1977)

In brsr/tsk: Trimmed Spearman-Karber Method

Example dose-response curves from Hamilton (1977)

Description

These are the example dose-response curves given in Hamilton (1977). Note that, as per Hamilton (1978), the confidence intervals given in Hamilton (1977) for these data sets are incorrect.

Usage

data(hamilton)

Format

A list containing ten data frames: dr1a, dr1b, dr1c, dr1d, dr1e, dr4a, dr4b, dr4c, dr4d, dr4e,

Source

Hamilton, 1977.

References

Hamilton, M. A.; Russo, R. C.; Thurston, R. V. Trimmed Spearman-Karber Method for Estimating Median Lethal Concentrations in Toxicity Bioassays. Enviro. Sci. Tech. 1977, 11 (7), 714-719. http://dx.doi.org/10.1021/es60130a004

Ibid, 1978, 12 (4), 417. http://dx.doi.org/10.1021/es60140a017

Examples

#Create data set of mean and confidence intervals for comparison to 
#the results from the EPA's program
data(hamilton)
p <- 2*pnorm(2)-1
for(input in hamilton){
   input$p<-input$r/input$n
 
   res0<-tsk(input,trim=0,conf.level=p)
   res5<-tsk(input,trim=0.05,conf.level=p)
   res10<-tsk(input,trim=0.1,conf.level=p)
   res20<-tsk(input,trim=0.2,conf.level=p)
   
   print(c(res0$LD50,res5$LD50,res10$LD50,res20$LD50))
   print(c(res0$conf.int[1],res5$conf.int[1],
            res10$conf.int[1],res20$conf.int[1]))
   print(c(res0$conf.int[2],res5$conf.int[2],
            res10$conf.int[2],res20$conf.int[2]))
   print("-")
}

brsr/tsk documentation built on Jan. 3, 2024, 6:51 p.m.