In charlotte-ngs/lbgfs2020: Livestock Breeding and Genomics (Fall 2020)

knitr::opts_chunk$set(echo = FALSE, results = "asis")
knitr::knit_hooks$set(hook_convert_odg = rmdhelp::hook_convert_odg)

Motivation

• Want to find location of important "genes"
• Draft of complete sequence of Human genome in 2000
• Function of different regions of genomes not known for large parts

$\rightarrow$ Associate locations in the genome with function

Association

#rmdhelp::use_odg_graphic(ps_path = 'odg/conserved-marker-segment.odg')
knitr::include_graphics(path = "odg/conserved-marker-segment.png")

Single Marker Regression Tests

\begin{equation} y = Wb + Xg + e \end{equation}

Genome-Wide Association Experiments Using Haplotypes

• Haplotypes as groups of SNP

Fitting All Markers Simultaneously

$$y = 1^T \mu + Xg + e$$

charlotte-ngs/lbgfs2020 documentation built on Dec. 20, 2020, 5:39 p.m.