wgsea-package: Gene set enrichment analysis using Wilcoxon rank tests

Description Details Author(s) References Examples

Description

Gene set enrichment analysis (GSEA) is typically based on tests derived from the Kolmogorov-Smirnov, which is underpowered and a need for simpler methods has been identified. The wgsea package contains functions for conducting GSEA using a Wilcoxon test to test for differences in the distribution of p values between SNPs within the gene set under test and a control set of SNPs.

Details

Package: wgsea
Type: Package
Version: 1.0
Date: 2012-04-18
License: GPL

See the vignette for further details.

Author(s)

Chris Wallace <chris.wallace@cimr.cam.ac.uk>

References

Irizarry, R. A.; Wang, C.; Zhou, Y. & Speed, T. P. Gene set enrichment analysis made simple. Stat Methods Med Res 2009, 18, 565-575

Heinig, M.; Petretto, E.; Wallace, C.; et al. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature 2010, 467, 460-464

Examples

1
vignette(package="wgsea")

chr1swallace/wgsea documentation built on May 13, 2019, 6:20 p.m.