median_normalization: Column wise median normalization of the data matrix

In const-ae/proDD: Identifying Differentially Abundant Proteins from Label-Free Mass Spectrometry Data

Description

The method calculates for each sample the median change (i.e. the difference between the observed value and the row average) and substracts it from each row. Missing values are ignored in the procedure. The method is based on the assumption that a majority of the rows did not change.

Usage

median_normalization(X)

## S4 method for signature 'SummarizedExperiment'
median_normalization(X)

## S4 method for signature 'MSnSet'
median_normalization(X)

Arguments

X	a matrix of proteins and samples

Value

the normalized matrix

Methods (by class)

• SummarizedExperiment: S4 method of median_normalization for SummarizedExperiment

• MSnSet: S4 method of median_normalization for MSnSet

const-ae/proDD documentation built on Jan. 14, 2020, 9:34 a.m.