dcgerard/mupdog: Flexible Genotyping for Polyploids

Implements empirical Bayes approaches to genotype polyploids from next generation sequencing data while accounting for allelic bias, overdispersion, and sequencing error. The main function is flexdog(), which allows the specification of many different genotype distributions. An experimental function that takes into account varying levels of relatedness is implemented in mupdog(). Also provided are functions to simulate genotypes, rgeno(), and read-counts, rflexdog(), as well as functions to calculate oracle genotyping error rates, oracle_mis(), and correlation with the true genotypes, oracle_cor(). These latter two functions are useful for read depth calculations. Run browseVignettes(package = "updog") in R for example usage. See also Gerard et al. (2018) <doi:10.1534/genetics.118.301468> for details on the implemented methods.

Getting started

Package details

Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
dcgerard/mupdog documentation built on Nov. 11, 2018, 5:25 p.m.