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.github/.gitignore
.github/workflows/R-CMD-check.yaml
.github/workflows/pkgdown.yaml
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DESCRIPTION
INSTALL
LICENSE
NAMESPACE
NEWS.md
R/bench.R
R/boin.R
R/ccd.R
R/cpe.R
R/crm.R
R/data.R
R/dtp.R
R/dutycycle.R
R/enhance.R
R/exact.R
R/extendr-wrappers.R
R/hyperprior.R
R/mclapply.R
R/precautionary-package.R
R/simulate_trials.R
R/sysdata.rda
R/three3.R
R/toxicity_generators.R
README.md
configure
data/viola_dtp.rda
demo/00Index
demo/EscRisk.R
docs/404.html
docs/LICENSE-text.html
docs/apple-touch-icon-120x120.png
docs/apple-touch-icon-152x152.png
docs/apple-touch-icon-180x180.png
docs/apple-touch-icon-60x60.png
docs/apple-touch-icon-76x76.png
docs/apple-touch-icon.png
docs/articles/DTP-vs-Korn94.html
docs/articles/DTP-vs-Korn94_files/DiagrammeR-styles-0.2/styles.css
docs/articles/DTP-vs-Korn94_files/accessible-code-block-0.0.1/empty-anchor.js
docs/articles/DTP-vs-Korn94_files/grViz-binding-1.0.6.1/grViz.js
docs/articles/DTP-vs-Korn94_files/header-attrs-2.7/header-attrs.js
docs/articles/DTP-vs-Korn94_files/header-attrs-2.8/header-attrs.js
docs/articles/DTP-vs-Korn94_files/header-attrs-2.9/header-attrs.js
docs/articles/DTP-vs-Korn94_files/htmlwidgets-1.5.3/htmlwidgets.js
docs/articles/DTP-vs-Korn94_files/htmlwidgets-1.5.4/htmlwidgets.js
docs/articles/DTP-vs-Korn94_files/viz-1.8.2/viz.js
docs/articles/FDA-proactive.html
docs/articles/FDA-proactive_files/accessible-code-block-0.0.1/empty-anchor.js
docs/articles/FDA-proactive_files/figure-html/hyperprior-1.png
docs/articles/FDA-proactive_files/header-attrs-2.7/header-attrs.js
docs/articles/FDA-proactive_files/header-attrs-2.8/header-attrs.js
docs/articles/FDA-proactive_files/header-attrs-2.9/header-attrs.js
docs/articles/FDA-proactive_files/kePrint-0.0.1/kePrint.js
docs/articles/FDA-proactive_files/lightable-0.0.1/lightable.css
docs/articles/Intro.html
docs/articles/Intro_files/accessible-code-block-0.0.1/empty-anchor.js
docs/articles/Intro_files/figure-html/Raleigh-distribution-1.png
docs/articles/Intro_files/figure-html/hyperprior-1.png
docs/articles/Intro_files/figure-html/unnamed-chunk-3-1.png
docs/articles/Intro_files/header-attrs-2.7/header-attrs.js
docs/articles/Intro_files/header-attrs-2.8/header-attrs.js
docs/articles/Intro_files/header-attrs-2.9/header-attrs.js
docs/articles/Intro_files/kePrint-0.0.1/kePrint.js
docs/articles/Intro_files/lightable-0.0.1/lightable.css
docs/articles/MCSE-Free.html
docs/articles/MCSE-Free_files/accessible-code-block-0.0.1/empty-anchor.js
docs/articles/MCSE-Free_files/figure-html/kraken-plot-1.png
docs/articles/MCSE-Free_files/header-attrs-2.7/header-attrs.js
docs/articles/MCSE-Free_files/header-attrs-2.8/header-attrs.js
docs/articles/MCSE-Free_files/header-attrs-2.9/header-attrs.js
docs/articles/MCSE-Free_files/kePrint-0.0.1/kePrint.js
docs/articles/MCSE-Free_files/lightable-0.0.1/lightable.css
docs/articles/Safety-Schematic-via-CPE.html
docs/articles/Safety-Schematic-via-CPE_files/accessible-code-block-0.0.1/empty-anchor.js
docs/articles/Safety-Schematic-via-CPE_files/figure-html/VIOLA-dose-scaling-1.png
docs/articles/Safety-Schematic-via-CPE_files/figure-html/contourplot-1.png
docs/articles/Safety-Schematic-via-CPE_files/figure-html/fatalities-vs-kappa-1.png
docs/articles/Safety-Schematic-via-CPE_files/figure-html/skeleton-as-expectation-1.png
docs/articles/Safety-Schematic-via-CPE_files/figure-html/skeleton-log-match-1.png
docs/articles/Safety-Schematic-via-CPE_files/header-attrs-2.9/header-attrs.js
docs/articles/index.html
docs/authors.html
docs/bootstrap-toc.css
docs/bootstrap-toc.js
docs/card.png
docs/docsearch.css
docs/docsearch.js
docs/favicon-16x16.png
docs/favicon-32x32.png
docs/favicon.ico
docs/index.html
docs/link.svg
docs/logo.svg
docs/news/index.html
docs/pkgdown.css
docs/pkgdown.js
docs/pkgdown.yml
docs/reference/Boin-class.html
docs/reference/Ccd-class.html
docs/reference/Cpe-class.html
docs/reference/Cpe3_3-class.html
docs/reference/Crm-class.html
docs/reference/HyperMTDi-class.html
docs/reference/Rplot001.png
docs/reference/applied_crm.html
docs/reference/as.data.table.exact.html
docs/reference/as.data.table.precautionary.html
docs/reference/calculate_dtps.html
docs/reference/cohorts_of_n.html
docs/reference/crm.html
docs/reference/crmh.html
docs/reference/crmh_xo.html
docs/reference/exact.html
docs/reference/extend.html
docs/reference/figures/card.png
docs/reference/figures/logo.svg
docs/reference/format.safetytab.html
docs/reference/hyper_mtdi_lognormal-class.html
docs/reference/index.html
docs/reference/mtdi_lognormal-class.html
docs/reference/ordinalizer.html
docs/reference/phase1_sim.html
docs/reference/plan.html
docs/reference/plot-mtdi_distribution-ANY-method.html
docs/reference/plot-mtdi_generator-ANY-method.html
docs/reference/plot_dutycycle.html
docs/reference/precautionary-package.html
docs/reference/print.exact.html
docs/reference/print.hyper.html
docs/reference/print.precautionary.html
docs/reference/safety_kable.html
docs/reference/simulate_trials.html
docs/reference/simulation_function.u_i.html
docs/reference/stop_for_excess_toxicity_empiric.html
docs/reference/summary.exact.html
docs/reference/summary.precautionary.html
docs/reference/test_draw_samples.html
docs/reference/viola_dtp.html
docs/sitemap.xml
exec/Makefile
exec/T2.tab
exec/T3.tab
exec/T4.tab
exec/T5.tab
exec/T6.tab
exec/T7.tab
exec/T8.tab
exec/esc.pl
exec/make_sysdata_TUb.R
exec/prolog/BOIN25-2-6-24.tab
exec/prolog/BOIN25-3-6-24.tab
exec/prolog/BOIN25-4-6-24.tab
exec/prolog/BOIN25-4-9-24.tab
exec/prolog/BOIN_get.oc.R
exec/prolog/aliquots.pl
exec/prolog/benchmarking.pl
exec/prolog/boin.R
exec/prolog/boin.pl
exec/prolog/ccd.pl
exec/prolog/ccd_check.pl
exec/prolog/designs.pl
exec/prolog/dsl.pl
exec/prolog/factorial.pl
exec/prolog/inconceivable.pl
exec/prolog/monot.pl
exec/prolog/qbeta.pl
exec/prolog/retro.pl
exec/prolog/rolling.pl
exec/prolog/subsumption.pl
exec/prolog/swi.pl
exec/prolog/tally.pl
exec/prolog/testD2
exec/prolog/three3.pl
exec/scryer.pl
exec/sicstus.pl
inst/WORDLIST
inst/shiny-apps/EscRisk/app.R
inst/shiny-apps/EscRisk/www/events.js
inst/shiny-apps/EscRisk/www/help.js
inst/shiny-apps/EscRisk/www/intro.js
inst/shiny-apps/EscRisk/www/introjs.css
inst/shiny-apps/EscRisk/www/tweaks.css
inst/testdata/BOIN25-3-6-24.tab
inst/testdata/BOIN25-4-6-24.tab
man/Boin-class.Rd
man/Ccd-class.Rd
man/Cpe-class.Rd
man/Cpe3_3-class.Rd
man/Crm-class.Rd
man/HyperMTDi-class.Rd
man/as.data.table.exact.Rd
man/as.data.table.precautionary.Rd
man/cohorts_of_n.Rd
man/crm.Rd
man/crmh.Rd
man/crmh_xo.Rd
man/exact.Rd
man/extend.Rd
man/figures/logo.svg
man/format.safetytab.Rd
man/hyper_mtdi_lognormal-class.Rd
man/mtdi_lognormal-class.Rd
man/ordinalizer.Rd
man/phase1_sim.Rd
man/plan.Rd
man/plot-mtdi_distribution-ANY-method.Rd
man/plot-mtdi_generator-ANY-method.Rd
man/plot_dutycycle.Rd
man/precautionary-package.Rd
man/print.exact.Rd
man/print.hyper.Rd
man/print.precautionary.Rd
man/safety_kable.Rd
man/simulate_trials.Rd
man/simulation_function.u_i.Rd
man/stop_for_excess_toxicity_empiric.Rd
man/summary.exact.Rd
man/summary.precautionary.Rd
man/test_draw_samples.Rd
man/viola_dtp.Rd
pkgdown/_pkgdown.yml
precautionary.Rproj
src/.gitignore
src/Makevars
src/Makevars.win
src/entrypoint.c
src/rust/Cargo.toml
src/rust/src/lib.rs
tests/manual/crm-numerics.R
tests/manual/pending.R
tests/manual/speed.R
tests/testthat.R
tests/testthat/test-boin.R
tests/testthat/test-crm.R
tests/testthat/test-enhance.R
tests/testthat/test-exact.R
tests/testthat/test-fractionation.R
tests/testthat/test-viola-dtp.R
vignettes/DTP-vs-Korn94.Rmd
vignettes/FDA-proactive.Rmd
vignettes/Intro.Rmd
vignettes/MCSE-Free.Rmd
vignettes/Safety-Schematic-via-CPE.Rmd
vignettes/precautionary-package.bib