NEWS.md

In dcnorris/precautionary: Safety Diagnostics for Dose-Escalation Trial Designs

precautionary 0.2.6-1

Changes

• Restored Windows build via passthru implementation of precautionary:::mclapply
• Refactored non-portable Makevars one-liner export CARGO_HOME = ...
• Added vignette on MCSE-Free CRM Performance & Safety Evaluation

precautionary 0.2.6

Changes

• EscRisk app displays CPE progress via 'odometer'
• EscRisk app lets user set max enrollment in range 20:30
• Restrict to OS_type: unix, as feasible CPE demands fork-based parallelism

precautionary 0.2.5

Changes

• Overhauled EscRisk shiny app to use CPE

precautionary 0.2.4

Changes

• Refined version numbering scheme to 0..-
• Implemented CPE as R6 superclass 'Cpe'
• Implemented Cumulative-Cohort Designs (CCDs) in 'Cpe' subclass 'Ccd'
• Implemented BOIN design as 'Boin' subclass of 'Ccd'
• Executable specification for CCD and BOIN in exec/prolog/
• Demoted package dtpcrm from a 'Depends' to a 'Suggests'

precautionary 0.2-3

Changes

• Parallelized Crm$trace_paths method
• Added 'MCSE-Free' calibration vignette

precautionary 0.2-2

Changes

• Implements R6 class to wrap CRM functions, with caching to speed DTP
• Implements faster versions of certain objective functions from package 'dtpcrm'
• Explicitly integrate() over c(-Inf,Inf) in 'crm' function (as per documentation)
• Implements faster version of dtpcrm::stop_for_excess_toxicity_empiric
• Corrected overloaded use of 'C' variable in text of DTP vignette

precautionary 0.2-1

Changes

• Added vignette 'Generalized dose-escalation safety schematics via DTP'
• Corrected a few typos

precautionary 0.2

Changes

• Added a Prolog program to exhaustively enumerate 3+3 trial outcomes

precautionary 0.1-5

Changes

• Accommodate new 'true_prob_eff' arg in escalation::simulate_trials

precautionary 0.1-4

Changes

• Added vignette for a regulatory application

precautionary 0.1-3

Changes

• Added the EscRisk shiny app, runnable by demo(EscRisk)

precautionary 0.1-2

Changes

• Simulations are now extensible, via extend.(precautionary|hyper) methods
• No longer using or depending on distr6, eliminating object creation overhead
• Hyper-simulations no longer have a superfluous 'K' (within-hyperprior-draw) dimension
• Sim summary()'s $safety component has prepended class 'safetytab'
• The format.safetytab() method shows significant digits in accordance with MCSEs

precautionary 0.1-1

• First public release

dcnorris/precautionary documentation built on Feb. 5, 2022, 12:13 p.m.