pneumovac: Pneumococcal Conjugate Vaccine Trial
In djrabideau/permuter: Randomization tests and confidence intervals
pneumovac R Documentation
Pneumococcal Conjugate Vaccine Trial
Description
The Pneumococcal Conjugate Vaccine Trial was a cluster randomized trial
carried out from 1997 to 2000 to assess the safety and efficacy of a
seven-valent conjugate pneumococcal vaccine (O'Brien et al., 2003). The
study population was Navajo and White Mountain Apache children younger
than 2 years, a group with one of the highest documented rates of invasive
pneumococcal disease in the world at that time. A total of 38 geographic
areas were randomized: 19 areas were offered pneumococcal vaccine and 19
were offered a comparator (meningococcal vaccine). These data, made available
by Hayes and Moulton (2017) on Harvard Dataverse, include a
random subsample of 449 children drawn from the original 8,292 trial
participants.
Usage
pneumovac
Format
A data frame with 449 observations and 4 variables:
- randunit
numeric, distinct for each randomised geographic area
- bpepisodes
number of bacterial pneumonia episodes
- spnvac
test vaccine: 0=meningococcal comparator, 1=pneumococcal vaccine
- fakeid
recoded individual participant id
Source
https://dataverse.harvard.edu/dataverse/crt
References
Hayes, R. J. and Moulton, L. H. (2017). Cluster Randomised Trials 2nd
edition. New York: Chapman and Hall/CRC.
O'Brien, K. L. et al. (2003). Efficacy and safety of seven-valent conjugate
pneumococcal vaccine in American Indian children: group randomised trial.
Lancet 362, 355–361.
djrabideau/permuter documentation built on Jan. 9, 2025, 11:45 p.m.
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| pneumovac | R Documentation |
Pneumococcal Conjugate Vaccine Trial
Description
The Pneumococcal Conjugate Vaccine Trial was a cluster randomized trial carried out from 1997 to 2000 to assess the safety and efficacy of a seven-valent conjugate pneumococcal vaccine (O'Brien et al., 2003). The study population was Navajo and White Mountain Apache children younger than 2 years, a group with one of the highest documented rates of invasive pneumococcal disease in the world at that time. A total of 38 geographic areas were randomized: 19 areas were offered pneumococcal vaccine and 19 were offered a comparator (meningococcal vaccine). These data, made available by Hayes and Moulton (2017) on Harvard Dataverse, include a random subsample of 449 children drawn from the original 8,292 trial participants.
Usage
pneumovac
Format
A data frame with 449 observations and 4 variables:
- randunit
numeric, distinct for each randomised geographic area
- bpepisodes
number of bacterial pneumonia episodes
- spnvac
test vaccine: 0=meningococcal comparator, 1=pneumococcal vaccine
- fakeid
recoded individual participant id
Source
https://dataverse.harvard.edu/dataverse/crt
References
Hayes, R. J. and Moulton, L. H. (2017). Cluster Randomised Trials 2nd edition. New York: Chapman and Hall/CRC.
O'Brien, K. L. et al. (2003). Efficacy and safety of seven-valent conjugate pneumococcal vaccine in American Indian children: group randomised trial. Lancet 362, 355–361.
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