average_toxicity: Average Toxicity Number

Description Usage Arguments Value References

Description

Calculate the Average Toxicity Number.

Usage

1
average_toxicity(dose, dose_set, true_prob, theta)

Arguments

dose

a numerical matrix of assigned doses for each step of the trial (column) and for each trial (row).

dose_set

a numerical vector of allowable doses in the trial.

true_prob

a numerical vector of the true probabilities associated with 'dose_set'.

theta

a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.

Value

Average Toxicity Number.

References

Cheung, Y. K. (2011). Dose finding by the continual reassessment method. CRC Press.


dnzmarcio/ewoc documentation built on Sept. 28, 2021, 6:52 a.m.