pbc_mayo: Mayo Clinic Primary Biliary Cirrhosis Data

In emilelatour/tidytableone: Tidy construction of "Table 1"

Mayo Clinic Primary Biliary Cirrhosis Data

Description

A nearly identical data set found in appendix D of Fleming and Harrington.

The data is from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 1984. A total of 424 PBC patients, referred to Mayo Clinic during that ten-year interval, met eligibility criteria for the randomized placebo controlled trial of the drug D-penicillamine. The first 312 cases in the data set participated in the randomized trial and contain largely complete data. The additional 112 cases did not participate in the clinical trial, but consented to have basic measurements recorded and to be followed for survival. Six of those cases were lost to follow-up shortly after diagnosis, so the data here are on an additional 106 cases as well as the 312 randomized participants.

Usage

pbc_mayo

Format

A tibble with 418 observations on 20 variables.

id

Patient ID

time

Number of days between registration and the earlier of death, transplantion, or study analysis time in July, 1986

status

Histologic stage of disease (needs biopsy)

trt

Drug treatment

age

Age in years

sex

Sex

ascites

Presence of ascites

hepato

Presence of hepatomegaly or enlarged liver

spiders

Blood vessel malformations in the skin

edema

Presence of edema

bili

Serum bilirunbin (mg/dl)

chol

Serum cholesterol (mg/dl)

albumin

Serum albumin (g/dl)

copper

Urine copper (ug/day)

alk_phos

Alkaline phosphotase (U/liter)

ast

Aspartate aminotransferase, once called SGOT (U/ml)

trig

Triglycerides (mg/dl)

platelet

Platelets per cubic ml/1000

protime

Standardised blood clotting time

stage

Histologic stage of disease

Source

Therneau and P Grambsch (2000), Modeling Survival Data: Extending the Cox Model, Springer-Verlag, New York. ISBN: 0-387-98784-3.

Examples

pbc_mayo

library(dplyr)
dplyr::glimpse(pbc_mayo)

emilelatour/tidytableone documentation built on Jan. 6, 2025, 9:20 a.m.