erl3data: Concentration response data from 200 ER assay curves

In ericwatt/toxboot: Bootstrap Methods for 'ToxCast' High Throughput Screening Data

Description

A dataset containing the output from toxbootQueryToxCast. A representative assay from each vendor was chosen to pass to toxbootQueryToxCast, and a random sampling of 200 m4ids were then selected from this output.

Usage

erl3data

Format

A data.table with 5580 rows and 16 variables:

• m3id : unique identifier for each concentration response value

• spid : sample id

• aeid : assay endpoint id

• logc : log10 of the uM concentration

• resp : response value

• m4id : unique identifier for the concentration response curve

• bmad : baseline median absolute deviation. A measure of baseline noise that is used in the fitting routine by tcplFit and is used as by toxboot as a measurement of noise when boot_method = smooth.

Details

The assays chosen were:

• NVS_NR_bER

• OT_ER_ERaERa_1440

• ATG_ERa_TRANS_up

• TOX21_ERa_LUC_BG1_Agonist

• ACEA_T47D_80hr_Positive

Source

https://www.epa.gov/chemical-research/toxicity-forecaster-toxcasttm-data/

ericwatt/toxboot documentation built on May 16, 2019, 8:41 a.m.