regulonluad: Human Lung Adenocarcinoma context-specific ARACNe interactome

In federicogiorgi/aracne.networks: ARACNe-inferred gene networks from TCGA tumor datasets

Description

The interactome is a human Lung Adenocarcinoma context-specific regulatory network reverse engineered by the ARACNE-AP algorithm. The interactome is contained in a list object of S3 class ‘regulon’ where each element represent a transcriptional regulator (transcription factor) and contains two vectors: (1) a named numeric vector indicating the mode of regulation (MoR) for each target gene, whose ID is indicated by the names attribute of the vector. (2) a numeric vector indicating the confidence score for the TF-target interaction.

Usage

data(regulonluad)

Value

Object of class regulon (regulon-class) containing network data generated by ARACNe-AP.

References

Giorgi,F.M. et al. (2016) ARACNe-AP: Gene Network Reverse Engineering through Adaptive Partitioning inference of Mutual Information. Bioinformatics doi: 10.1093/bioinformatics/btw216.

Examples

             data(regulonluad)
             write.regulon(regulonluad,n=10)
        

federicogiorgi/aracne.networks documentation built on May 16, 2019, 12:13 p.m.