Description Objects from the Class Slots Methods References Examples
This is the S4 class for constructing Bryant and Day designs. This can be converted to the standard format using properties
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Objects can be created by calls of the form new("binom_two_bryantday", ...)
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optimal
:Object of class "data.frame"
, single row data.frame containing the optimal design under H0
minmax
:Object of class "data.frame"
, Single row data.frame containing the minmax design under H0
all.fit
:Object of class "data.frame"
, A data.frame containing all designs which satisfy the required alpha and power specified for the trial
signature(x = "binom_two_bryantday")
(x, t, r, pra, prb,
pta, ptb, futility_critical_value = 0.2,
efficacy_critical_value = 0.35, toxicity_critical_value = 0.3,
no_toxicity_critical_value = 0.1)
Class object which you wish to get properties for
A vector of the probability of response and toxicity for the simulation scenarios used to compute frequentist properties. The print function requires the first to be the alternative hypothesis and subsequent entries to be the three null hypotheses. This can be run with any scenario when not using the print method
A vector of the number of patients each interim and final analysis will occur at
Numeric values for the beta prior distribution to be used
Four values, for the critical values to be used as thresholds for the posterior distribution
Bryant J, Day R. Incorporating toxicity considerations into the design of two-stage phase II clinical trials. Biometrics 1995; 51: 1372-1383.
1 | showClass("binom_two_bryantday")
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