n2r: Sample size reassessment rules

In floatofmath/blindConfidence: Simulation of estimation after blinded interim analysis

Usage

n2r(S1OS, delta0, n1, adj = FALSE, n2min = 0, n2max = Inf, cf = 1,
  alpha = 0.025, beta = 0.2)

Arguments

S1OS	interim estimate of the standard deviation
delta0	assumed effect size
n1	first-stage sample size
adj	should the adjusted rule be used
n2min	minimum second-stage sample size
n2max	maximum second-stage sample size
cf	correction facton
alpha	significance level (one-sided)
beta	targeted Type II error rate

Value

adjusted second-stage sample size

Author(s)

Florian Klinglmueller

Examples

## Example from Kieser et al. (2003)
n1 = 15
S1OS = 6
delta0 = 5.5
n2r(S1OS,delta0,n1)
n2r(S1OS,delta0,n1,adj=T)

floatofmath/blindConfidence documentation built on May 16, 2019, 1:20 p.m.