BCIplot: Plot based on Binomial confidence interval

In ganluan123/FlagAE: Flag adverse events by Bayesian methods

Description

Both functions BCIplot plot the top AEs with top ptnum (one parameter, an integer) highest difference of incidence rate between treatment and control group(treatment - control). The incidence and confidence interval from treatment and control group are plotted. AEs from the same SoC is plotted in same color. Function BCItable return a table containing information about AE selected.

Usage

BCIplot(aedata, ptnum = 10, conf.level = 0.95)

BCItable(aedata, ptnum = 10, conf.level = 0.95)

Arguments

aedata	output from function preprocess
ptnum	positive integer, number of AEs to be plotted, default is 10
conf.level	number between 0 and 1, confidence level for constructing confidence interval, default is 0.95

Details

The incidence and confidence interval for both control and treatment group are calculated by Fisher exact test. BCIplot plots out the AEs with confidence interval, while BCItable output a table containig the information of AEs in the plot. The table from BCItable has the following columns:
AEBODSYS: SOC of the AE
AEDECOD: PT term of the AE
AEc: number of occurence of the AE in control group
AEt: number of occurence of the AE in treatment group
Nc: number of subjects in control group
Nt: number of subjects in treatment group
c_mean: incidence of the AE in control group
c_lowerbd: lower bound of the confidence interval of incidence the AE in control group
c_upperbd: upper bound of the confidence interval of incidence the AE in control group
t_mean: incidence of the AE in treatment group
t_lowerbd: lower bound of the confidence interval of incidence the AE in treatment group
t_upperbd: upper bound of the confidence interval of incidence the AE in treatment group
mean_diff: difference of incidence of the AE in treatment group and control group

See Also

preprocess

Examples

## Not run: 
data(ADAE)
data(ADSL)
AEdata<-preprocess(adsl=ADSL, adae=ADAE)
BCIplot(aedata=AEdata)
BCIplot(aedata=AEdata, ptnum=15, conf.level=0.9)
BCItable(aedata=AEdata)
BCItable(aedata=AEdata, ptnum=15, conf.level=0.9)

## End(Not run)

ganluan123/FlagAE documentation built on Nov. 4, 2019, 1:02 p.m.