examples: QMD Examples

In guiastrennec/modelviz: Generation of QMD for NONMEM outputs

QMD Examples

Description

A list of 6 qmd_info examples on the pharmacokinetic models for nevirapine (onecomp), miltefosine (twocomp), ciclosporin (threecomp), felodipine (gitt), bedaquiline (metabolite) and theophylline (pbpk).

Format

A list of 6 levels: onecomp, twocomp, threecomp, gitt metabolite and pbpk.

Details

The examples file contains the following:

• examples$onecomp nevirapine PK model qmd_info

• examples$twocomp miltefosine PK model qmd_info

• examples$threecomp ciclosporin PK model qmd_info

• examples$gitt felodipine PK model qmd_info

• examples$metabolite bedaquiline PK model qmd_info

• examples$pbpk theophylline PBPK model qmd_info

Each of these examples contain the following:

• descr model description

• theta theta typical values and RSE (%) for fixed effects

• omega omega typical values (%) and RSE (%) for inter subject variability

• data individual model parameter read from a patab file

• advan nonmem ADVAN subroutine

• parsed_comp the parsed compartment information

• parsed_arrow the parsed arrow information

Source

onecomp: D. Elsherbiny et al. Population pharmacokinetics of nevirapine in combination with rifampicin-based short course chemotherapy in HIV- and tuberculosis-infected South African patients. Eur J Clin Pharmacol. 65:71–80. (2009)

twocomp: T. Dorlo et al. Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients. Antimicrob. Agents Chemother. 52:8, 2855–2860. (2008)

threecomp: S. Fanta et al. Developmental pharmacokinetics of ciclosporin – a population pharmacokinetic study in paediatric renal transplant candidates. British Journal of Clinical Pharmacology. 64:6, 772–784. (2007)

gitt: E. Hénin et al. A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model. The AAPS Journal, 14:2, 155-163. (2012)

metabolite: E. Svensson et al. Model-Based Estimates of the Effects of Efavirenz on Bedaquiline Pharmacokinetics and Suggested Dose Adjustments for Patients Coinfected with HIV and Tuberculosis. Antimicrobial Agents and Chemotherapy, 57:6, 2780-2787. (2013)

pbpk: S. Björkman. Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. British Journal of Clinical Pharmacology. 59:6, 691–704. (2004)

Examples

## Not run: 
# One-compartment model
qmd(examples$onecomp)

# Two-compartment model
qmd(examples$twocomp)

# Three-compartment model
qmd(examples$threecomp)

# GITT model
qmd(examples$gitt, rank = c(1,2,2,2,2,2,3,4,5,5))

# Metabolite
qmd(examples$metabolite, rank = c(1,2,3,4,5,6,7,7,6,7,6,7))

# PBPK model
qmd(examples$pbpk, pbpk_layout = TRUE)

## End(Not run)

guiastrennec/modelviz documentation built on Feb. 16, 2024, 8:14 p.m.