README.md

In hanjunwei-lab/PriorCD: Prioritizing Cancer Drugs for Interested Cancer

PriorCD

Prioritizing Cancer Drugs for Interested Cancer

Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.

how to install

Install the development version from Github:

Installation method：

1. library(devtools); 
   install_github("hanjunwei-lab/PriorCD")
2. install.packages("PriorCD")

Use：
library(PriorCD)

Please cite the following article when using PriorCD:

Di, J., B. Zheng, Q. Kong, Y. Jiang, S. Liu, Y. Yang, X. Han, Y. Sheng, Y. Zhang, L. Cheng, and J. Han, Prioritization of candidate cancer drugs based on a drug functional similarity network constructed by integrating pathway activities and drug activities. Mol Oncol, 2019. 13(10): p. 2259-2277.

hanjunwei-lab/PriorCD documentation built on July 5, 2020, 11:02 a.m.