fitness: Survival fitness function using the Restricted Mean Survival...
In harpomaxx/galgo: An Evolutionary Framework for the Identification and Study of Prognostic Gene Expression Signatures in Cancer
Description
Usage
Arguments
Value
Author(s)
References
Examples
Description
Survival fitness function using the Restricted Mean Survival Time (RMST) of each group as proposed by Dehbi & Royston et al. (2017).
Usage
1
fitness(OS, clustclass, period)
Arguments
OS
a survival object with survival data of the patients evaluated
clustclass
a numeric vector with the group label for each patient
period
a number representing the period of time to evaluate in the RMST calculation
Value
The function computes the Harmonic mean of the differences between Restricted Mean Survival Time (RMST) of consecutive survival curves multiplied by the number of comparisons.
Author(s)
Martin E Guerrero-Gimenez, mguerrero@mendoza-conicet.gob.ar
References
Dehbi Hakim-Moulay, Royston Patrick, Hackshaw Allan. Life expectancy difference and life expectancy ratio: two measures of treatment effects in randomized trials with non-proportional hazards BMJ 2017; 357 :j2250 https://www.bmj.com/content/357/bmj.j2250
Examples
1
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5
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7
## Not run:
rna_luad<-use_rna_luad()
clinical <- rna_luad$TCGA$pheno_data
OS <- survival::Surv(time=clinical$time,event=clinical$status)
fitness(OS,clustclass= clinical$Wilk.Subtype, 1825)
## End(Not run)
harpomaxx/galgo documentation built on Aug. 11, 2020, 3:07 p.m.
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Description Usage Arguments Value Author(s) References Examples
Description
Survival fitness function using the Restricted Mean Survival Time (RMST) of each group as proposed by Dehbi & Royston et al. (2017).
Usage
1 | fitness(OS, clustclass, period)
|
Arguments
OS |
a |
clustclass |
a numeric vector with the group label for each patient |
period |
a number representing the period of time to evaluate in the RMST calculation |
Value
The function computes the Harmonic mean of the differences between Restricted Mean Survival Time (RMST) of consecutive survival curves multiplied by the number of comparisons.
Author(s)
Martin E Guerrero-Gimenez, mguerrero@mendoza-conicet.gob.ar
References
Dehbi Hakim-Moulay, Royston Patrick, Hackshaw Allan. Life expectancy difference and life expectancy ratio: two measures of treatment effects in randomized trials with non-proportional hazards BMJ 2017; 357 :j2250 https://www.bmj.com/content/357/bmj.j2250
Examples
1 2 3 4 5 6 7 | ## Not run:
rna_luad<-use_rna_luad()
clinical <- rna_luad$TCGA$pheno_data
OS <- survival::Surv(time=clinical$time,event=clinical$status)
fitness(OS,clustclass= clinical$Wilk.Subtype, 1825)
## End(Not run)
|
R Package Documentation
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We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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