Description Details model kinfit kinsim See Also
Fitting the protein-ligand sensorgram data collected from a BLI biosensor or SPR experiment.
BLI Biosensor became a popular method to study protein-protein, and protein-ligand interactions recently. However, the data fitting is a challenge because the fitting program availabe has only a limited number of conventioanal models. The present package is the first time to use R to fit this kind of data. A novel model was developed in the package, which enable us to study the protein self-homodimerization using the biosensor method.
The pldfit provide two models:
1. The "simple1to1" model: the protein immobilized on the pin has one binding site for the ligand, usally in a 96-well plate.
2. The dimer model: the protein dimerize itself. So it will binding itself in the solusion biside the interaction on the pin.
The function to fit the sensorgram data. there are two models: "simple1to1" and "dimer" model.
The function to simulate the sensorgram data. there are two models: "simple1to1" and "dimer" model.
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