pldfit: pldfit: Fitting the Protein-Ligand Sensorgram Data

Description Details model kinfit kinsim See Also

Description

Fitting the protein-ligand sensorgram data collected from a BLI biosensor or SPR experiment.

Details

BLI Biosensor became a popular method to study protein-protein, and protein-ligand interactions recently. However, the data fitting is a challenge because the fitting program availabe has only a limited number of conventioanal models. The present package is the first time to use R to fit this kind of data. A novel model was developed in the package, which enable us to study the protein self-homodimerization using the biosensor method.

model

The pldfit provide two models:

1. The "simple1to1" model: the protein immobilized on the pin has one binding site for the ligand, usally in a 96-well plate.

2. The dimer model: the protein dimerize itself. So it will binding itself in the solusion biside the interaction on the pin.

kinfit

The function to fit the sensorgram data. there are two models: "simple1to1" and "dimer" model.

kinsim

The function to simulate the sensorgram data. there are two models: "simple1to1" and "dimer" model.

See Also

kinfit

kinsim


huangrh/pldfit documentation built on May 17, 2019, 9:10 p.m.