R codes for the (adaptive) Sum of Powered Score ('SPU' and 'aSPU') tests, inverse variance weighted Sum of Powered score ('SPUw' and 'aSPUw') tests and genebased and some pathway based association tests (Pathway based Sum of Powered Score tests ('SPUpath'), adaptive 'SPUpath' ('aSPUpath') test, 'GEEaSPU' test for multiple traits  single 'SNP' (single nucleotide polymorphism) association in generalized estimation equations, 'MTaSPUs' test for multiple traits  single 'SNP' association with Genome Wide Association Studies ('GWAS') summary statistics, Genebased Association Test that uses an extended 'Simes' procedure ('GATES'), Hybrid Setbased Test ('HYST') and extended version of 'GATES' test for pathwaybased association testing ('GATESSimes'). ). The tests can be used with genetic and other data sets with covariates. The response variable is binary or quantitative. Summary; (1) Single trait'SNP' set association with individuallevel data ('aSPU', 'aSPUw', 'aSPUr'), (2) Single trait'SNP' set association with summary statistics ('aSPUs'), (3) Single traitpathway association with individuallevel data ('aSPUpath'), (4) Single traitpathway association with summary statistics ('aSPUsPath'), (5) Multiple traitssingle 'SNP' association with individuallevel data ('GEEaSPU'), (6) Multiple traits single 'SNP' association with summary statistics ('MTaSPUs'), (7) Multiple traits'SNP' set association with summary statistics('MTaSPUsSet'), (8) Multiple traitspathway association with summary statistics('MTaSPUsSetPath').
Package details 


Author  IlYoup Kwak and others (See Author(s) in each function manual) 
Maintainer  IlYoup Kwak <[email protected]> 
License  GPL3 
Version  1.48 
URL  https://github.com/ikwak2/aSPU 
Package repository  View on GitHub 
Installation 
Install the latest version of this package by entering the following in R:

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