IDOLOptimizedCpGsBloodExtended450k: IDOL Optimized CpGs for extended blood DNA methylation...

IDOLOptimizedCpGsBloodExtended450kR Documentation

IDOL Optimized CpGs for extended blood DNA methylation deconvolution 450k

Description

This object is a vector of length 1500 consisting of the names of the IDOL optimized CpGs. These CpGs are used as the backbone for deconvolution with 450k and were selected because their methylation signature differs across the twelve normal leukocyte subtypes.

Usage

IDOLOptimizedCpGsBloodExtended450k

Format

An object of class "character" of length 1200.

The format is: chr [1:1500] "cg18857618" "cg00644351" "cg09177577" "cg21091766" ...

References

LA Salas et al. (2021). Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling. (Under review)

LA Salas et al. (2018). An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray. Genome Biology 19, 64. doi: 10.1186/s13059-018-1448-7

DC Koestler et al. (2016). Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL). BMC bioinformatics. 17, 120. doi: 10.1186/s13059-018-1448-7.

Examples

# Do not run
# data("IDOLOptimizedCpGsBloodExtended450k")

immunomethylomics/FlowSorted.BloodExtended.EPIC documentation built on Jan. 29, 2024, 8:43 p.m.