projectWBCnew: projectWBCnew

In immunomethylomics/IDOL: IDentifying Optimal DNA methylation Libraries (IDOL)

Description

This function predicts the underlying cellular composition of heterogeneous tissue types (i.e., WB) using the constrained projection procedure described by Houseman et al., (2012).

Usage

projectWBCnew(Y, coefWBC, contrastWBC = NULL, nonnegative = TRUE)

Arguments

Y:	A J x N matrix of methylation beta-values collected from mixed/ heterogeneous biospecimen (i.e., WB). Target set.
coefWBC:	A J x K projection matrix;, i.e., within-cell type mean methylation matrix across J DMLs and K many cell types
contrastWBC:	Contrast for cell composition predictions. The user needn't modify this nonnegative: Should cell predictions be nonnegative. Defaults to TRUE

Value

A N x K matrix of cell proportion estimates across the K cell types for each of the N subjects contained in the Target Set.

immunomethylomics/IDOL documentation built on July 9, 2020, 5:14 a.m.