CMEA is a tool for cell morphology enrichment analysis and link transcriptomic alterations with cell morphological phenotypes. In our approach we (1) map the transcriptomic profile of a query against the L1000 LINCS repository, (2) create a gene set repository for cell morphological features (CM), (3) identify the top CMs associated with alterations and analyze their direction of regulation, and (4) model a regulatory network of cell morphological phenotypes.
|Author||Isar Nassiri, Matthew McCall|
|Bioconductor views||Regression Software StatisticalMethod|
|Maintainer||Isar Nassiri <[email protected]>|
|Package repository||View on GitHub|
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