R implementation of a multivariate meta-analysis of randomized controlled trials (RCT) with the difference in restricted mean survival times (RMSTD). Use this package with individual patient level data from an RCT for a time-to-event outcome to determine combined effect estimates according to 4 methods: 1) a univariate meta-analysis using observed treatment effects, 2) a univariate meta-analysis using effects predicted by fitted Royston-Parmar flexible parametric models, 3) multivariate meta-analysis with analytically derived covariance, 4) multivariate meta-analysis with bootstrap derived covariance. This package computes all combined effects and provides an RMSTD curve with combined effect estimates and their confidence intervals.
Package details |
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Author | Isabelle Weir [aut, cre], Lu Tian [aut], Ludovic Trinquart [aut] |
Maintainer | Isabelle Weir <iweir@bu.edu> |
License | GPL-2 |
Version | 1.0.0 |
URL | https://github.com/iweir/metaRMST |
Package repository | View on GitHub |
Installation |
Install the latest version of this package by entering the following in R:
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