simulate_trial_with_control2: Simulate a trial with fixed allocation to control group
In jatotterdell/mfittrial: Functions for MFIT Trial

simulate_trial_with_control2

R Documentation

Simulate a trial with fixed allocation to control group

Description

Simulate a trial with fixed allocation to control group

Usage

simulate_trial_with_control2(
  n_seq = c(100, 200, 300, 400),
  dat = simulate_continuous_outcome(nsubj = max(n_seq)),
  eff_eps = function(FI) 0.98,
  sup_eps = function(FI) 0.98,
  fut_eps = function(FI) 0.98,
  delta = 2,
  alloc = rep(1/4, 4),
  prior = c(int_prior_mean = 40, int_prior_sd = 5, b_prior_sd = 5, a0 = 3, b0 = 5),
  brar = 2,
  brar_k = 0.5,
  allow_stopping = TRUE,
  make_dt = TRUE,
  ctr = contr.treatment,
  ..
)

Arguments

`n_seq`	The sequence of analyses by number of subjects with 12 week observation
`dat`	The dataset for this particular simulation
`eff_eps`	Effective decision threshold (relative to control) as function of fraction of information
`sup_eps`	Superiority decision threshold (relative to active treatments) as function of fraction of information
`fut_eps`	Futility threshold as a function of fraction of trial information.
`delta`	Futility reference value
`alloc`	Initial allocation ratio
`brar`	Update allocation ratio using BRAR