fmd_scaled_ttest: Allometric scaling for flow-mediated dilation: Independent...

In jcherubini/Rtery: A suite of tools for endothelial function analysis

Allometric scaling for flow-mediated dilation: Independent sample t-tests

Description

This function calculates allometrically-scaled flow-mediated dilation responses for independent sample t-tests and returns the corresponding comparisons between groups. The function will also return back-transformed means, standard errors, and 95% confidence intervals.

Usage

fmd_scaled_ttest(dat)

Arguments

dat	data frame object; does not have to be named 'dat', but the columns that correspond to peak artery diameter, baseline artery diameter, and group (or condition) must be labeled "dpeak", "dbase", and "group", respectively.

Examples

Simulated data with peak and baseline artery diameters from 12 participants:

EXAMPLE 1: Allometric scaling not required
dat <- data.frame(participant = c("P1", "P2", "P3", "P4", "P5", "P6", "P7", "P8", "P9", "P10", "P11", "P12"), dpeak = c(4.1, 3.2, 6.5, 5.9, 4.3, 2.1, 4.0, 6.3, 3.3, 4.9, 5.2, 7.1), dbase = c(4.0, 2.9, 6.0, 5.7, 4.1, 2.0, 3.7, 6.2, 3.2, 4.3, 5.1, 6.9), group = as.factor(c("NS", "NS", "NS", "NS", "SD", "SD", "SD", "SD", "SR", "SR", "SR", "SR")))
res <- fmd_scaled_ttest(dat)

EXAMPLE 2: Allometric scaling required and calculated:
dat <- data.frame(dpeak = rnorm(30, 4.27, 1.12), dbase = rnorm(30, 4.16, 1.21)*0.8, group = as.factor(c(rep("NS", 10), rep("SD", 10), rep("SR", 10))))
res <- fmd_scaled_ttest(dat)

jcherubini/Rtery documentation built on April 17, 2025, 3:07 p.m.