NEWS.md

In keaven/gsDesign2: Group Sequential Design with Non-Constant Effect

gsDesign2 0.1.0, May, 2021

• Updated AHR vignette to introduce average hazard ratio concept well
• Added arbitrary distribution vignette to demonstrate s2pwe() function
• Corrected calculations in AHR() when using stratified population
• Release for Regulatory/Industry Symposium training

gsDesign2 0.0.0.9006, December, 2019

• Added eEvents_df() vignette explaining methods thoroughly
• Updated eEvents_df() to simplify output under simple=FALSE option

gsDesign2 0.0.0.9005, December, 2019

• Updated docs directory to correct reference materials in web site
• Minor fix in eAccrual

gsDesign2 0.0.0.9004, November, 2019

• Moved new simulation functions to simtrial package (simfix, simfix2simPWSurv, pMaxCombo).

gsDesign2 0.0.0.9003, November, 2019

• Tried to make AHR and simfix more compatible with each other.
• Improved vignette for group sequential design.
• Added web site for documentation and vignettes in docs/index.html.
• Added support functions for to support approximation using and visualization of the piecewise model.

gsDesign2 0.0.0.2, October, 2019

• Update to AHR() to output trial duration, expected events and average hazard ratio in a tibble.
• Vignette AHRvignette demonstrating sample size computations for fixed design under non-proportional hazards assumptions.
• Vignette gsNPH demonstrating sample size computations for group sequential design under non-proportional hazards assumptions.
• Initial implementation of pMaxCombo() to compute p-value for MaxCombo test; pMaxComboVignette demonstrates this capability.

gsDesign2 0.0.0.1, September, 2019

• Computations based on piecewise constant enrollment and piecewise exponential failure rate
• Expected event count calculation for each different hazard ratios in eEvents_df()
• Average hazard ratio computation based on expected event counts in AHR()
• Vignette demonstrating fixed sample size computation with simulation to verify power

keaven/gsDesign2 documentation built on Oct. 13, 2022, 8:42 p.m.